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EDC1 Edc1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852650, updated on 9-Dec-2024

Summary

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Official Symbol
EDC1
Official Full Name
Edc1p
Primary source
SGD:S000003190
Locus tag
YGL222C
See related
AllianceGenome:SGD:S000003190; FungiDB:YGL222C; VEuPathDB:YGL222C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables mRNA binding activity. Involved in deadenylation-dependent decapping of nuclear-transcribed mRNA and positive regulation of translation in response to stress. Located in cytoplasm and nucleus. Part of RNA decapping complex. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See EDC1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (80659..81186, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene nucleotidase Neighboring gene Golgi transport complex subunit COG1 Neighboring gene uncharacterized protein Neighboring gene Bol2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The enhancer of decapping proteins, Edc1p and Edc2p, bind RNA and stimulate the activity of the decapping enzyme. Schwartz D, et al. RNA, 2003 Feb. PMID 12554867, Free PMC Article
  2. Enhancer of decapping proteins 1 and 2 are important for translation during heat stress in Saccharomyces cerevisiae. Neef DW, et al. Mol Microbiol, 2009 Sep. PMID 19682251, Free PMC Article
  3. Analysis of recombinant yeast decapping enzyme. Steiger M, et al. RNA, 2003 Feb. PMID 12554866, Free PMC Article
  4. The yeast EDC1 mRNA undergoes deadenylation-independent decapping stimulated by Not2p, Not4p, and Not5p. Muhlrad D, et al. EMBO J, 2005 Mar 9. PMID 15706350, Free PMC Article
  5. Dcp1 links coactivators of mRNA decapping to Dcp2 by proline recognition. Borja MS, et al. RNA, 2011 Feb. PMID 21148770, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In this report the authors show that strains lacking Edc2, as well as the paralogous protein Edc1, are compromised for growth under persistent heat stress.
    Title: Enhancer of decapping proteins 1 and 2 are important for translation during heat stress in Saccharomyces cerevisiae.
  2. The 3' UTR of the EDC1 mRNA is sufficient for both protection from deadenylation and deadenylation-independent decapping and an extended poly(U) tract within the 3' UTR is required.
    Title: The yeast EDC1 mRNA undergoes deadenylation-independent decapping stimulated by Not2p, Not4p, and Not5p.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of translation in response to stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of RNA decapping complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of RNA decapping complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Edc1p
NP_011293.1
  • RNA-binding protein that activates mRNA decapping directly; binds to mRNA substrate and enhances activity of decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress; EDC1 has a paralog, EDC2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    80659..81186 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181087.1 → NP_011293.1  TPA: Edc1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011293.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVB3, P53080
    UniProtKB/TrEMBL
    A6ZTW9, C8Z833
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53080.1

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