CHC1 clathrin heavy chain [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: CHC1
Official Full Name: clathrin heavy chain
Primary source: SGD:S000003174
Locus tag: YGL206C
See related: AllianceGenome:SGD:S000003174; FungiDB:YGL206C; VEuPathDB:YGL206C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: SWA5
Summary: Predicted to enable clathrin light chain binding activity. Involved in Golgi to endosome transport; cortical actin cytoskeleton organization; and endocytosis. Predicted to be located in several cellular components, including clathrin-coated pit; cytoplasmic vesicle membrane; and cytosol. Predicted to be part of clathrin complex. Predicted to be active in actin cortical patch. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 56. Orthologous to human CLTC (clathrin heavy chain) and CLTCL1 (clathrin heavy chain like 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See CHC1 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (102543..107504, complement)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data suggest that additional or alternative binding sites exist on the the clathrin heavy chain (HC) N-terminal domain propeller to help facilitate the recruitment of clathrin to sites of vesicle formation.
Title: Clathrin functions in the absence of the terminal domain binding site for adaptor-associated clathrin-box motifs.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables clathrin light chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables clathrin light chain binding	IEA Inferred from Electronic Annotation more info
enables structural molecule activity	IEA Inferred from Electronic Annotation more info
enables structural molecule activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi to endosome transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in Golgi to endosome transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cortical actin cytoskeleton organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cortical actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in receptor-mediated endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in actin cortical patch	IBA Inferred from Biological aspect of Ancestor more info
located_in bounding membrane of organelle	IEA Inferred from Electronic Annotation more info
part_of clathrin coat of coated pit	IEA Inferred from Electronic Annotation more info
part_of clathrin coat of trans-Golgi network vesicle	IEA Inferred from Electronic Annotation more info
part_of clathrin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of clathrin complex	IEA Inferred from Electronic Annotation more info
part_of clathrin vesicle coat	TAS Traceable Author Statement more info	PubMed
located_in clathrin-coated pit	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: clathrin heavy chain

NP_011309.1

Clathrin heavy chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; the clathrin triskelion is a trimeric molecule composed of three heavy chains that radiate from a vertex and three light chains which bind noncovalently near the vertex of the triskelion; the light chain (CLC1) is thought to regulate function

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

102543..107504 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181071.1 → NP_011309.1 TPA: clathrin heavy chain [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011309.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VTU9, P22137

UniProtKB/TrEMBL

A6ZTY3, G2WDQ2

Conserved Domains (5) summary

smart00299
Location:1280 → 1422

CLH; Clathrin heavy chain repeat homology

pfam00637
Location:1134 → 1270

Clathrin; Region in Clathrin and VPS

pfam01394
Location:262 → 294

Clathrin_propel; Clathrin propeller repeat

pfam09268
Location:338 → 360

Clathrin-link; Clathrin, heavy-chain linker

pfam13838
Location:362 → 425

Clathrin_H_link; Clathrin-H-link