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DSD1 D-serine ammonia-lyase DSD1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852679, updated on 9-Dec-2024

Summary

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Official Symbol
DSD1
Official Full Name
D-serine ammonia-lyase DSD1
Primary source
SGD:S000003164
Locus tag
YGL196W
See related
AllianceGenome:SGD:S000003164; FungiDB:YGL196W; VEuPathDB:YGL196W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables D-serine ammonia-lyase activity. Involved in D-serine metabolic process. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See DSD1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (129883..131169)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Yip4p Neighboring gene Mds3p Neighboring gene Gcn1p Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel zinc-dependent D-serine dehydratase from Saccharomyces cerevisiae. Ito T, et al. Biochem J, 2008 Jan 15. PMID 17937657
  2. Enzymatic assay of D-serine using D-serine dehydratase from Saccharomyces cerevisiae. Ito T, et al. Anal Biochem, 2007 Dec 15. PMID 17869212
  3. Insights into the structural properties of D-serine dehydratase from Saccharomyces cerevisiae: an FT-IR spectroscopic and in silico approach. Baldassarre M, et al. Biochimie, 2011 Mar. PMID 21130133
  4. Turning pyridoxal-5'-phosphate-dependent enzymes into thermostable binding proteins: D-Serine dehydratase from baker's yeast as a case study. Baldassarre M, et al. Biochimie, 2012 Feb. PMID 21896305
  5. Role of zinc ion for catalytic activity in d-serine dehydratase from Saccharomyces cerevisiae. Ito T, et al. FEBS J, 2012 Feb. PMID 22176976

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that the Y203 does not participate in the protonation of the pyridine nitrogen (N1) of PLP, and d-serine dehydratase Dsd1p uses the cofactor in an N1-unprotonated state.
    Title: Reaction mechanism of Zn2+-dependent d-serine dehydratase: role of a conserved tyrosine residue interacting with pyridine ring nitrogen of pyridoxal 5'-phosphate.
  2. Data suggest that d-Serine dehydratase catalyzes the alpha-hydrogen abstraction and hydroxyl group elimination in a concerted fashion.
    Title: Role of zinc ion for catalytic activity in d-serine dehydratase from Saccharomyces cerevisiae.
  3. zinc is involved in the elimination of the hydroxy group of D-serine and D-threonine. D-Serine dehydratase of S. cerevisiae is probably the first example of a eukaryotic D-serine dehydratase and that of a specifically zinc-dependent pyridoxal enzyme
    Title: A novel zinc-dependent D-serine dehydratase from Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables D-serine ammonia-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables D-serine ammonia-lyase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables D-serine ammonia-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in D-serine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in D-serine metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to toxic substance IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
D-serine ammonia-lyase DSD1
NP_011319.2
  • D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc; may play a role in D-serine detoxification; L-serine is not a substrate

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    129883..131169
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181061.1 → NP_011319.2  TPA: D-serine ammonia-lyase DSD1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011319.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTV7, P53095
    UniProtKB/TrEMBL
    A6ZTZ2, B3LHP5, B5VID7, C8Z856, G2WDR0, N1P2U1
    Conserved Domains (1) summary
    cd06817
    Location:13 → 428
    PLPDE_III_DSD; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Eukaryotic D-Serine Dehydratase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53095.2

Gene LinkOut

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