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HOS2 histone deacetylase HOS2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852681, updated on 9-Dec-2024

Summary

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Official Symbol
HOS2
Official Full Name
histone deacetylase HOS2
Primary source
SGD:S000003162
Locus tag
YGL194C
See related
AllianceGenome:SGD:S000003162; FungiDB:YGL194C; VEuPathDB:YGL194C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
RTL1
Summary
Enables NAD-independent histone deacetylase activity. Involved in negative regulation of meiotic nuclear division; positive regulation of stress-activated MAPK cascade; and regulation of DNA-templated transcription. Acts upstream of or within positive regulation of translation. Located in nuclear periphery. Part of Set3 complex. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human HDAC3 (histone deacetylase 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See HOS2 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (140368..141726, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Gcn1p Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene mRNA (N6-adenosine)-methyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RNA Polymerase II Dependent Crosstalk between H4K16 Deacetylation and H3K56 Acetylation Promotes Transcription of Constitutively Expressed Genes. Khan P, et al. Mol Cell Biol, 2023. PMID 37937370, Free PMC Article
  2. SUB1 Plays a Negative Role during Starvation Induced Sporulation Program in Saccharomyces cerevisiae. Gupta R, et al. PLoS One, 2015. PMID 26147804, Free PMC Article
  3. Histone deacetylase Hos2 regulates protein expression noise by potentially modulating the protein translation machinery. Lin WH, et al. Nucleic Acids Res, 2024 Jul 22. PMID 38783136, Free PMC Article
  4. Comparative studies of genome-wide maps of nucleosomes between deletion mutants of elp3 and hos2 genes of Saccharomyces cerevisiae. Matsumoto T, et al. PLoS One, 2011 Jan 28. PMID 21297980, Free PMC Article
  5. Polyamines inhibit the yeast histone deacetylase. Vu QA, et al. FEBS Lett, 1987 Aug 10. PMID 3301411

See all (105) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results uncover an unexpected role for histone deacetylases (Rpd3 and Hos2) in promoting Spt6 interaction with elongating Pol II.
    Title: Histone deacetylases and phosphorylated polymerase II C-terminal domain recruit Spt6 for cotranscriptional histone reassembly.
  2. observed the formation of a reversible cytosolic "stationary-phase granule" by Hos2, a nuclear histone deacetylase. In the stationary phase, hos2 mutants display reduced viability.
    Title: The histone deacetylase Hos2 forms an Hsp42-dependent cytoplasmic granule in quiescent yeast cells.
  3. both Elp3-induced acetylation and Hos2-induced deacetylation influence the nucleosome positions in the promoters of 24 genes
    Title: Comparative studies of genome-wide maps of nucleosomes between deletion mutants of elp3 and hos2 genes of Saccharomyces cerevisiae.
  4. the Hos2p/Set3p complex (SET3C) is a novel component critical for cell survival in response to secretory stress.
    Title: Hos2p/Set3p deacetylase complex signals secretory stress through the Mpk1p cell integrity pathway.
  5. Two histone deacetylases, RPD3 and HOS2, are required for the activation of DNA damage-inducible genes RNR3 and HUG1.
    Title: Histone deacetylases RPD3 and HOS2 regulate the transcriptional activation of DNA damage-inducible genes.
  6. Hos2 and Set3 function at tRNA genes to promote Ty1 integration
    Title: Hos2 and Set3 promote integration of Ty1 retrotransposons at tRNA genes in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables histone H3K14 deacetylase activity, hydrolytic mechanism IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K4 deacetylase activity, hydrolytic mechanism IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K9 deacetylase activity, hydrolytic mechanism IEA
Inferred from Electronic Annotation
more info
  
enables histone H4K12 deacetylase activity, hydrolytic mechanism IEA
Inferred from Electronic Annotation
more info
  
enables histone H4K16 deacetylase activity, hydrolytic mechanism IEA
Inferred from Electronic Annotation
more info
  
enables histone H4K5 deacetylase activity, hydrolytic mechanism IEA
Inferred from Electronic Annotation
more info
  
enables histone H4K8 deacetylase activity, hydrolytic mechanism IEA
Inferred from Electronic Annotation
more info
  
enables histone deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone deacetylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone deacetylase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in epigenetic regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of stress-activated MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Rpd3L-Expanded complex HDA PubMed 
part_of Rpd3L-Expanded complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Set3 complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in nuclear periphery IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
histone deacetylase HOS2
NP_011321.1
  • Histone deacetylase and subunit of Set3 and Rpd3L complexes; required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; co-localizes with Cmr1p in nuclear foci in response to DNA damage by MMS

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    140368..141726 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181059.1 → NP_011321.1  TPA: histone deacetylase HOS2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011321.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTW0, P53096
    UniProtKB/TrEMBL
    A6ZTZ5, B3LHP2, C7GX01, G2WDR3, N1P6D2
    Conserved Domains (1) summary
    cd11598
    Location:28 → 338
    HDAC_Hos2; Class I histone deacetylases including ScHos2 and SpPhd1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53096.1

Gene LinkOut

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