COX13 cytochrome c oxidase subunit VIa [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: COX13
Official Full Name: cytochrome c oxidase subunit VIa
Primary source: SGD:S000003159
Locus tag: YGL191W
See related: AllianceGenome:SGD:S000003159; FungiDB:YGL191W; VEuPathDB:YGL191W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables enzyme regulator activity. Contributes to cytochrome-c oxidase activity. Involved in aerobic respiration and mitochondrial respirasome assembly. Located in mitochondrion. Part of respiratory chain complex IV. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease recessive intermediate D and mitochondrial complex IV deficiency nuclear type 18. Orthologous to several human genes including COX6A2 (cytochrome c oxidase subunit 6A2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See COX13 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (144808..145197)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Point mutations are introduced into subunit I of a mutant mitochondrial yeast strain with a histidine tag on the nuclear-encoded Cox13 subunit shows mechanistic effects of mutations on respiratory growth.
Title: Construction of histidine-tagged yeast mitochondrial cytochrome c oxidase for facile purification of mutant forms.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
contributes_to cytochrome-c oxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables enzyme regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables enzyme regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in aerobic respiration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial electron transport, cytochrome c to oxygen	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial respirasome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oxidative phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
part_of respiratory chain complex IV	IBA Inferred from Biological aspect of Ancestor more info
part_of respiratory chain complex IV	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cytochrome c oxidase subunit VIa

NP_011324.1

Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

144808..145197

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181056.1 → NP_011324.1 TPA: cytochrome c oxidase subunit VIa [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011324.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VTW3, P32799

UniProtKB/TrEMBL

A6ZTZ7, B3LHP0, C7GX03, C8Z860, G2WDR5, N1P2U6

Conserved Domains (1) summary

pfam02046
Location:3 → 125

COX6A; Cytochrome c oxidase subunit VIa