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CWC23 U2-type spliceosomal complex subunit CWC23 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852749, updated on 4-Jan-2025

Summary

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Official Symbol
CWC23
Official Full Name
U2-type spliceosomal complex subunit CWC23
Primary source
SGD:S000003096
Locus tag
YGL128C
See related
AllianceGenome:SGD:S000003096; FungiDB:YGL128C; VEuPathDB:YGL128C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in spliceosomal complex disassembly. Part of U2-type spliceosomal complex. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See CWC23 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (269293..270144, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene mRNA guanylyltransferase Neighboring gene mitochondrial 37S ribosomal protein RSM23 Neighboring gene mediator complex subunit SOH1 Neighboring gene Scs3p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cwc23 is a component of the NTR complex and functions to stabilize Ntr1 and facilitate disassembly of spliceosome intermediates. Su YL, et al. Nucleic Acids Res, 2018 Apr 20. PMID 29390077, Free PMC Article
  2. Disruption of six novel Saccharomyces cerevisiae genes reveals that YGL129c is necessary for growth in non-fermentable carbon sources, YGL128c for growth at low or high temperatures and YGL125w is implicated in the biosynthesis of methionine. Tizón B, et al. Yeast, 1999 Jan 30. PMID 10029993
  3. Co-evolution of spliceosomal disassembly interologs: crowning J-protein component with moonlighting RNA-binding activity. Raut S, et al. Curr Genet, 2019 Apr. PMID 30467716
  4. Network of general and specialty J protein chaperones of the yeast cytosol. Sahi C, et al. Proc Natl Acad Sci U S A, 2007 Apr 24. PMID 17438278, Free PMC Article
  5. Cwc23, an essential J protein critical for pre-mRNA splicing with a dispensable J domain. Sahi C, et al. Mol Cell Biol, 2010 Jan. PMID 19822657, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in spliceosomal complex disassembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spliceosomal complex disassembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of U2-type spliceosomal complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
U2-type spliceosomal complex subunit CWC23
NP_011387.2
  • Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to E. coli DnaJ and other DnaJ-like proteins and to S. pombe Cwf23p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    269293..270144 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180993.1 → NP_011387.2  TPA: U2-type spliceosomal complex subunit CWC23 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011387.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VU20, P52868, Q6B1S2
    UniProtKB/TrEMBL
    B3LHI8, C7GX63, C8Z8C2, G2WDX4, N1P1Q0
    Conserved Domains (2) summary
    COG2214
    Location:14 → 228
    CbpA; Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription]
    pfam00226
    Location:15 → 84
    DnaJ; DnaJ domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52868.2

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