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VPS73 putative sugar transporter [ Saccharomyces cerevisiae S288C ]

Gene ID: 852774, updated on 9-Dec-2024

Summary

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Official Symbol
VPS73
Official Full Name
putative sugar transporter
Primary source
SGD:S000003072
Locus tag
YGL104C
See related
AllianceGenome:SGD:S000003072; FungiDB:YGL104C; VEuPathDB:YGL104C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable hexose transmembrane transporter activity. Involved in protein targeting to vacuole. Located in fungal-type vacuole membrane and mitochondrion. Human ortholog(s) of this gene implicated in epilepsy (multiple); glucose transporter type 1 deficiency syndrome (multiple); myelomeningocele; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including SLC2A4 (solute carrier family 2 member 4) and SLC2A9 (solute carrier family 2 member 9). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See VPS73 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (308713..310173, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Mlc1p Neighboring gene Arc1p Neighboring gene ribosomal 60S subunit protein L28 Neighboring gene 5'-deoxynucleotidase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A phylogenetic analysis of the sugar porters in hemiascomycetous yeasts. Palma M, et al. J Mol Microbiol Biotechnol, 2007. PMID 17587872
  2. RNAi expression tuning, microfluidic screening, and genome recombineering for improved protein production in Saccharomyces cerevisiae. Wang G, et al. Proc Natl Acad Sci U S A, 2019 May 7. PMID 31000602, Free PMC Article
  3. Prevacuolar compartment morphology in vps mutants of Saccharomyces cerevisiae. Hedman JM, et al. Cell Biol Int, 2007 Oct. PMID 17543551
  4. The Saccharomyces cerevisiae Ptc1 protein phosphatase attenuates G2-M cell cycle blockage caused by activation of the cell wall integrity pathway. Tatjer L, et al. Mol Microbiol, 2016 Aug. PMID 27169355
  5. Genomic screen for vacuolar protein sorting genes in Saccharomyces cerevisiae. Bonangelino CJ, et al. Mol Biol Cell, 2002 Jul. PMID 12134085, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables hexose transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in hexose transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monosaccharide transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting to vacuole HMP PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in fungal-type vacuole membrane HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative sugar transporter
NP_011411.3
  • Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family; VPS73 has a paralog, YBR241C, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    308713..310173 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180969.3 → NP_011411.3  TPA: putative sugar transporter [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011411.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VU42, P53142
    UniProtKB/TrEMBL
    A6ZU77, B3LHG8, C7GM21, C8Z8E4, N1P347
    Conserved Domains (1) summary
    cd17357
    Location:31 → 484
    MFS_GLUT_Class1_2_like; Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53142.1

Gene LinkOut

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