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SRM1 Ran guanyl-nucleotide exchange factor [ Saccharomyces cerevisiae S288C ]

Gene ID: 852782, updated on 9-Dec-2024

Summary

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Official Symbol
SRM1
Official Full Name
Ran guanyl-nucleotide exchange factor
Primary source
SGD:S000003065
Locus tag
YGL097W
See related
AllianceGenome:SGD:S000003065; FungiDB:YGL097W; VEuPathDB:YGL097W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MTR1; PRP20; TSM437
Summary
Enables guanyl-nucleotide exchange factor activity. Involved in nucleocytoplasmic transport and nucleus organization. Located in chromatin; cytoplasm; and nucleus. Orthologous to human RCC1 (regulator of chromosome condensation 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SRM1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (321782..323230)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene SNAP receptor USE1 Neighboring gene tRNA-His Neighboring gene Tos8p Neighboring gene tRNA-Glu

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nuclear PRP20 protein is required for mRNA export. Amberg DC, et al. EMBO J, 1993 Jan. PMID 7679070, Free PMC Article
  2. Analysis of yeast prp20 mutations and functional complementation by the human homologue RCC1, a protein involved in the control of chromosome condensation. Fleischmann M, et al. Mol Gen Genet, 1991 Jul. PMID 1865879
  3. Prp20, the Saccharomyces cerevisiae homolog of the regulator of chromosome condensation, RCC1, interacts with double-stranded DNA through a multi-component complex containing GTP-binding proteins. Lee A, et al. J Cell Sci, 1993 Sep. PMID 8270631
  4. A yeast mutant, PRP20, altered in mRNA metabolism and maintenance of the nuclear structure, is defective in a gene homologous to the human gene RCC1 which is involved in the control of chromosome condensation. Aebi M, et al. Mol Gen Genet, 1990 Oct. PMID 2277633
  5. The yeast SRM1 protein and human RCC1 protein share analogous functions. Clark KL, et al. Cell Regul, 1991 Oct. PMID 1666302, Free PMC Article

See all (90) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study reveals that Prp20p and RCC1 share similar Ran GTPase binding mode.
    Title: The 1.9Å crystal structure of Prp20p from Saccharomyces cerevisiae and its binding properties to Gsp1p and histones.
  2. Report interaction of transcriptional regulators with specific nucleosomes across the Saccharomyces genome.
    Title: Interaction of transcriptional regulators with specific nucleosomes across the Saccharomyces genome.
  3. Nup2p and the Ran guanylyl-nucleotide exchange factor, Prp20p, interact at specific chromatin regions and enable the NPC to play an active role in chromatin organization by facilitating the transition of chromatin between activity states.
    Title: The mobile nucleoporin Nup2p and chromatin-bound Prp20p function in endogenous NPC-mediated transcriptional control.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleus organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in poly(A)+ mRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to pheromone IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosomal subunit export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ran guanyl-nucleotide exchange factor
NP_011418.1
  • Nucleotide exchange factor for Gsp1p; localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p; human homolog of the RAN GEF, RCC1, can complement a temperature sensitive point mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    321782..323230
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180962.1 → NP_011418.1  TPA: Ran guanyl-nucleotide exchange factor [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011418.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VU48, P21827
    UniProtKB/TrEMBL
    A6ZU83, B3LHG2, B5VIM9, C7GW22, C8Z8F1, G2WE02, N1P1U3
    Conserved Domains (1) summary
    COG5184
    Location:15 → 477
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P21827.1

Gene LinkOut

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