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PAN2 poly(A)-specific ribonuclease [ Saccharomyces cerevisiae S288C ]

Gene ID: 852786, updated on 4-Jan-2025

Summary

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Official Symbol
PAN2
Official Full Name
poly(A)-specific ribonuclease
Primary source
SGD:S000003062
Locus tag
YGL094C
See related
AllianceGenome:SGD:S000003062; FungiDB:YGL094C; VEuPathDB:YGL094C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to poly(A)-specific ribonuclease activity. Involved in nuclear-transcribed mRNA poly(A) tail shortening and postreplication repair. Located in cytoplasm. Part of PAN complex. Orthologous to human PAN2 (poly(A) specific ribonuclease subunit PAN2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See PAN2 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (331118..334465, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene tRNA-Glu Neighboring gene Vps45p Neighboring gene Spc105p Neighboring gene nucleocytoplasmic transporter NUP145

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. 3'-UTR-dependent deadenylation by the yeast poly(A) nuclease. Lowell JE, et al. Genes Dev, 1992 Nov. PMID 1358757
  2. The yeast Pan2 protein is required for poly(A)-binding protein-stimulated poly(A)-nuclease activity. Boeck R, et al. J Biol Chem, 1996 Jan 5. PMID 8550599
  3. The structure of the Pan2-Pan3 core complex reveals cross-talk between deadenylase and pseudokinase. Schäfer IB, et al. Nat Struct Mol Biol, 2014 Jul. PMID 24880344
  4. Poly(A) tail length control in Saccharomyces cerevisiae occurs by message-specific deadenylation. Brown CE, et al. Mol Cell Biol, 1998 Nov. PMID 9774670, Free PMC Article
  5. Conceptual modeling of mRNA decay provokes new hypotheses. Somekh J, et al. PLoS One, 2014. PMID 25255440, Free PMC Article

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Crystal structures of Saccharomyces cerevisiae Pan2 in complex with RNA show that, surprisingly, Pan2 does not form canonical base-specific contacts. Instead, it recognizes the intrinsic stacked, helical conformation of poly(A) RNA.
    Title: The intrinsic structure of poly(A) RNA determines the specificity of Pan2 and Caf1 deadenylases.
  2. The exonuclease subunit Pan2 does not bind RNA by itself, but binds to an asymmetric Pan3 homodimer via an extensive, high-affinity interaction.
    Title: Structural basis for Pan3 binding to Pan2 and its function in mRNA recruitment and deadenylation.
  3. PAN2 and PAN3 are not required for mRNA poly(A) tail length control during de novo synthesis but may act in conjuction with Pab1p at a later stage in mRNA metabolism.
    Title: Yeast mRNA Poly(A) tail length control can be reconstituted in vitro in the absence of Pab1p-dependent Poly(A) nuclease activity.
  4. Accumulation of polyadenylated mRNAs at sites of transcription occurs in strains lacking the PAN2 or PAN3 subunits of the poly(A) nuclease PAN. PAN is identified as an important factor that couples 3' processing of pre-mRNAs to export.
    Title: Yeast poly(A)-binding protein, Pab1, and PAN, a poly(A) nuclease complex recruited by Pab1, connect mRNA biogenesis to export.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to poly(A)-specific ribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(A)-specific ribonuclease activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to poly(A)-specific ribonuclease activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear-transcribed mRNA poly(A) tail shortening IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear-transcribed mRNA poly(A) tail shortening IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nuclear-transcribed mRNA poly(A) tail shortening IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear-transcribed mRNA poly(A) tail shortening IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in postreplication repair IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of PAN complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of PAN complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of PAN complex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
poly(A)-specific ribonuclease
NP_011421.1
  • Catalytic subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex; complex acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    331118..334465 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180959.1 → NP_011421.1  TPA: poly(A)-specific ribonuclease [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011421.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VU51, P53010
    UniProtKB/TrEMBL
    A6ZU86, B3LHF9, B5VIN2, C7GW24, C8Z8F4, G2WE06, N1P354
    Conserved Domains (3) summary
    cd06143
    Location:907 → 1080
    PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2
    COG2319
    Location:15 → 352
    WD40; WD40 repeat [General function prediction only]
    pfam13423
    Location:505 → 829
    UCH_1; Ubiquitin carboxyl-terminal hydrolase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53010.1

Gene LinkOut

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