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HNM1 Hnm1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852803, updated on 9-Dec-2024

Summary

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Official Symbol
HNM1
Official Full Name
Hnm1p
Primary source
SGD:S000003045
Locus tag
YGL077C
See related
AllianceGenome:SGD:S000003045; FungiDB:YGL077C; VEuPathDB:YGL077C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CTR1
Summary
Enables (R)-carnitine transmembrane transporter activity; choline transmembrane transporter activity; and ethanolamine transmembrane transporter activity. Involved in amino-acid betaine transport; choline transport; and ethanolamine transport. Located in cell periphery and endoplasmic reticulum. Used to study proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See HNM1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (362225..363916, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Kxd1p Neighboring gene RNA-dependent ATPase DBP3 Neighboring gene ribosomal 60S subunit protein L7A Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Hypersaline stress induces the turnover of phosphatidylcholine and results in the synthesis of the renal osmoprotectant glycerophosphocholine in Saccharomyces cerevisiae. Kiewietdejonge A, et al. FEMS Yeast Res, 2006 Mar. PMID 16487344
  2. Sensitivity to nitrogen mustard in Saccharomyces cerevisiae is independently determined by regulated choline permease and DNA repair. Li Z, et al. Mutat Res, 1994 Sep. PMID 7520996
  3. 2-hydroxyethylhydrazine as a potent inhibitor of phospholipid methylation in yeast. Nikawa J, et al. Biochim Biophys Acta, 1983 Apr 13. PMID 6338930
  4. Cloning of a gene encoding choline transport in Saccharomyces cerevisiae. Nikawa J, et al. J Bacteriol, 1986 Apr. PMID 3514579, Free PMC Article
  5. Primary structure of the yeast choline transport gene and regulation of its expression. Nikawa J, et al. J Biol Chem, 1990 Sep 15. PMID 2203793

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. choline transport activity regulates phosphatidylcholine synthesis through choline transporter Hnm1 stability
    Title: Choline transport activity regulates phosphatidylcholine synthesis through choline transporter Hnm1 stability.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables (R)-carnitine transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables choline transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ethanolamine transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables gamma-aminobutyric acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in (R)-carnitine transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in (R)-carnitine transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in choline transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ethanolamine transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gamma-aminobutyric acid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycine betaine transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Hnm1p
NP_011438.1
  • Plasma membrane transporter for choline, ethanolamine, and carnitine; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol; human FLVCR2 (MFSD7c), a choline transporter involved in Fowler syndrome, can complement the yeast null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    362225..363916 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180942.1 → NP_011438.1  TPA: Hnm1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011438.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VU67, P19807
    UniProtKB/TrEMBL
    A6ZUA2, B3LHE3, C7GW38, C8Z8H0, G2WE22, N1P9Q6
    Conserved Domains (1) summary
    TIGR00907
    Location:45 → 521
    2A0304; amino acid permease (GABA permease)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P19807.1

Gene LinkOut

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