PKP2 protein kinase PKP2 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: PKP2
Official Full Name: protein kinase PKP2
Primary source: SGD:S000003027
Locus tag: YGL059W
See related: AllianceGenome:SGD:S000003027; FungiDB:YGL059W; VEuPathDB:YGL059W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables pyruvate dehydrogenase (acetyl-transferring) kinase activity. Involved in regulation of mitophagy. Located in mitochondrion. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease X-linked dominant 6 and branched-chain keto acid dehydrogenase kinase deficiency. Orthologous to several human genes including BCKDK (branched chain keto acid dehydrogenase kinase); PDK1 (pyruvate dehydrogenase kinase 1); and PDK3 (pyruvate dehydrogenase kinase 3). [provided by Alliance of Genome Resources, Jan 2025]
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Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	HDA more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables pyruvate dehydrogenase (acetyl-transferring) kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables pyruvate dehydrogenase (acetyl-transferring) kinase activity	IEA Inferred from Electronic Annotation more info
enables pyruvate dehydrogenase (acetyl-transferring) kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of acetyl-CoA biosynthetic process from pyruvate	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of glucose metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitophagy	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

NP_011456.5

Mitochondrial protein kinase; negatively regulates activity of the pyruvate dehydrogenase complex by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp1p and phosphatases Ptc5p and Ptc6p; relocalizes from mitochondrion to cytoplasm upon DNA replication stress

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The following sections contain reference sequences that belong to a specific genome build. Explain