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carbonyl reductase (NADPH-dependent) [ Saccharomyces cerevisiae S288C ]

Gene ID: 852844, updated on 9-Dec-2024

Summary

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Official Full Name
carbonyl reductase (NADPH-dependent)
Primary source
SGD:S000003007
Locus tag
YGL039W
See related
AllianceGenome:SGD:S000003007; FungiDB:YGL039W; VEuPathDB:YGL039W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables aldehyde dehydrogenase (NAD+) activity and carbonyl reductase (NADPH) activity. Involved in cellular ketone metabolic process and response to furfural. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (423961..425007)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene porphobilinogen synthase HEM2 Neighboring gene tRNA-Leu Neighboring gene initiation-specific alpha-1,6-mannosyltransferase Neighboring gene nicotinamidase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Efficient anaerobic whole cell stereoselective bioreduction with recombinant Saccharomyces cerevisiae. Katz M, et al. Biotechnol Bioeng, 2003 Dec 5. PMID 14574691
  2. Enantiodivergent, biocatalytic routes to both taxol side chain antipodes. Feske BD, et al. J Org Chem, 2005 Nov 11. PMID 16268655
  3. Direct enzyme assay evidence confirms aldehyde reductase function of Ydr541cp and Ygl039wp from Saccharomyces cerevisiae. Moon J, et al. Yeast, 2015 Apr. PMID 25656103
  4. Synthesis of optically pure 2-azido-1-arylethanols with isolated enzymes and conversion to triazole-containing beta-blocker analogues employing click chemistry. Ankati H, et al. J Org Chem, 2008 Aug 15. PMID 18630881
  5. Exploring redundancy in the yeast genome: an improved strategy for use of the cre-loxP system. Delneri D, et al. Gene, 2000 Jul 11. PMID 10903444

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. YDR541C and YGL039W encoded an aldehyde reductase.
    Title: Direct enzyme assay evidence confirms aldehyde reductase function of Ydr541cp and Ygl039wp from Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables aldehyde dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carbonyl reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on CH-OH group of donors IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in ketone metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to furfural IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 

General protein information

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Preferred Names
carbonyl reductase (NADPH-dependent)
NP_011476.1
  • Aldehyde reductase; reduces aliphatic aldehyde substrates using NADH as cofactor; shown to reduce carbonyl compounds to chiral alcohols

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    423961..425007
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180904.1 → NP_011476.1  TPA: carbonyl reductase (NADPH-dependent) [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011476.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUA0, P53183
    UniProtKB/TrEMBL
    A6ZUV6, B3LIQ0, B5VIS7, C7GT54, C8Z8K4, N1P396
    Conserved Domains (1) summary
    cd05227
    Location:7 → 324
    AR_SDR_e; aldehyde reductase, extended (e) SDRs
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53183.1

Gene LinkOut

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