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ALK1 protein kinase ALK1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852863, updated on 9-Dec-2024

Summary

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Official Symbol
ALK1
Official Full Name
protein kinase ALK1
Primary source
SGD:S000002989
Locus tag
YGL021W
See related
AllianceGenome:SGD:S000002989; FungiDB:YGL021W; VEuPathDB:YGL021W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein kinase activity. Acts upstream of or within mitotic morphogenesis checkpoint signaling. Predicted to be active in cytoplasm and nucleus. Orthologous to human HASPIN (histone H3 associated protein kinase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ALK1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (454785..457067)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Pib2p Neighboring gene dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3 Neighboring gene GET complex subunit GET1 Neighboring gene casein kinase 2 regulatory subunit CKB1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The YGL021 gene encodes a putative membrane protein with a putative leucine zipper motif. Chen WN, et al. Yeast, 1991 Apr. PMID 1882554
  2. Alk1 and Alk2 are two new cell cycle-regulated haspin-like proteins in budding yeast. Nespoli A, et al. Cell Cycle, 2006 Jul. PMID 16855400
  3. Yeast haspin kinase regulates polarity cues necessary for mitotic spindle positioning and is required to tolerate mitotic arrest. Panigada D, et al. Dev Cell, 2013 Sep 16. PMID 23973165
  4. Structure, function and evolution of haspin and haspin-related proteins, a distinctive group of eukaryotic protein kinases. Higgins JM. Cell Mol Life Sci, 2003 Mar. PMID 12737306, Free PMC Article
  5. Haspin Modulates the G2/M Transition Delay in Response to Polarization Failures in Budding Yeast. Galli M, et al. Front Cell Dev Biol, 2020. PMID 33585466, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We show that deletion of ALK1 and ALK2 haspin paralogs causes the mislocalization of polarisome components.
    Title: Yeast haspin kinase regulates polarity cues necessary for mitotic spindle positioning and is required to tolerate mitotic arrest.
  2. Overexpression of ALK2, but not of ALK1, causes a mitotic arrest, which is correlated to the kinase activity of the protein
    Title: Alk1 and Alk2 are two new cell cycle-regulated haspin-like proteins in budding yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T3 kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mitotic morphogenesis checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein kinase ALK1
NP_011494.1
  • Atypical protein kinase; along with paralog, ALK2, required for proper spindle positioning and nuclear segregation following mitotic arrest, proper organization of formins and polarisome components in mitosis, and survival after spindle assembly checkpoint delay; regulates the morphogenesis checkpoint in response to polarity insults through inactivation of Mih1p; phosphorylated in response to DNA damage; similar to mammalian haspins

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    454785..457067
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180886.1 → NP_011494.1  TPA: protein kinase ALK1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011494.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUB6, P43633
    UniProtKB/TrEMBL
    G2WE72, N1P5K8
    Conserved Domains (1) summary
    cl21453
    Location:211 → 760
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43633.2

Gene LinkOut

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