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BIL2 Bil2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852869, updated on 4-Jan-2025

Summary

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Official Symbol
BIL2
Official Full Name
Bil2p
Primary source
SGD:S000002983
Locus tag
YGL015C
See related
AllianceGenome:SGD:S000002983; FungiDB:YGL015C; VEuPathDB:YGL015C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Acts upstream of or within negative regulation of formin-nucleated actin cable assembly and protein localization to mating projection tip. Located in secretory vesicle and site of polarized growth. Is active in cytosol and mating projection tip. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See BIL2 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (465043..465435, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene arginyltransferase Neighboring gene Kap122p Neighboring gene Puf4p Neighboring gene drug-responsive transcription factor PDR1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The roles of yeast formins and their regulators Bud6 and Bil2 in the pheromone response. Magliozzi JO, et al. Mol Biol Cell, 2024 Jun 1. PMID 38656798, Free PMC Article
  2. Bil2 Is a Novel Inhibitor of the Yeast Formin Bnr1 Required for Proper Actin Cable Organization and Polarized Secretion. Rands TJ, et al. Front Cell Dev Biol, 2021. PMID 33634134, Free PMC Article
  3. A genome-wide visual screen reveals a role for sphingolipids and ergosterol in cell surface delivery in yeast. Proszynski TJ, et al. Proc Natl Acad Sci U S A, 2005 Dec 13. PMID 16330752, Free PMC Article
  4. Dissection of a complex phenotype by functional genomics reveals roles for the yeast cyclin-dependent protein kinase Pho85 in stress adaptation and cell integrity. Huang D, et al. Mol Cell Biol, 2002 Jul. PMID 12077337, Free PMC Article
  5. A visual screen of protein localization during sporulation identifies new components of prospore membrane-associated complexes in budding yeast. Lam C, et al. Eukaryot Cell, 2014 Mar. PMID 24390141, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of formin-nucleated actin cable assembly IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein localization to mating projection tip IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mating projection tip IDA
Inferred from Direct Assay
more info
 PubMed 
located_in prospore membrane HDA PubMed 
located_in secretory vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in site of polarized growth IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Bil2p
NP_011500.3
  • Formin inhibitor; inhibits Bnr1p-mediated actin filament nucleation but not elongation during vegetative growth; performs distinct but overlapping roles with Hof1p to control actin cable assembly and polarized secretion; spatially focuses Bni1p at mating projection tips, and with Bud6p organizes Bni1p into clusters that nucleate actin assembly during mating projection formation; bnr1 bil2 double mutants are inviable; localizes to the cytosol, secretory vesicles and sites of polarized growth

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    465043..465435 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180880.3 → NP_011500.3  TPA: Bil2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011500.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUC2, P33199
    UniProtKB/TrEMBL
    A6ZUX8, B3LIN0, C7GSA9, C8Z8M7, G2WE78, N1P3C6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P33199.1

Gene LinkOut

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