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ERG4 delta(24(24(1)))-sterol reductase [ Saccharomyces cerevisiae S288C ]

Gene ID: 852872, updated on 9-Dec-2024

Summary

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Official Symbol
ERG4
Official Full Name
delta(24(24(1)))-sterol reductase
Primary source
SGD:S000002980
Locus tag
YGL012W
See related
AllianceGenome:SGD:S000002980; FungiDB:YGL012W; VEuPathDB:YGL012W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables delta24(24-1) sterol reductase activity and delta24-sterol reductase activity. Involved in ergosterol biosynthetic process. Located in endoplasmic reticulum. Is active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ERG4 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (472855..474276)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Puf4p Neighboring gene drug-responsive transcription factor PDR1 Neighboring gene proteasome core particle subunit alpha 1 Neighboring gene Mpo1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sterol 24(28) methylene reductase in Saccharomyces cerevisiae. Neal WD, et al. J Bacteriol, 1977 Mar. PMID 14922, Free PMC Article
  2. Biochemical characterization and subcellular localization of the sterol C-24(28) reductase, erg4p, from the yeast saccharomyces cerevisiae. Zweytick D, et al. FEBS Lett, 2000 Mar 17. PMID 10722850
  3. Involvement of FgERG4 in ergosterol biosynthesis, vegetative differentiation and virulence in Fusarium graminearum. Liu X, et al. Mol Plant Pathol, 2013 Jan. PMID 22947191, Free PMC Article
  4. The identification of a gene family in the Saccharomyces cerevisiae ergosterol biosynthesis pathway. Lai MH, et al. Gene, 1994 Mar 11. PMID 8125337
  5. Inheritance of brewing-relevant phenotypes in constructed Saccharomyces cerevisiae × Saccharomyces eubayanus hybrids. Krogerus K, et al. Microb Cell Fact, 2017 Apr 21. PMID 28431563, Free PMC Article

See all (82) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables delta24(24-1) sterol reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables delta24(24-1) sterol reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables delta24(24-1) sterol reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables delta24-sterol reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ergosterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ergosterol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
delta(24(24(1)))-sterol reductase
NP_011503.1
  • C-24(28) sterol reductase; catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    472855..474276
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180877.1 → NP_011503.1  TPA: delta(24(24(1)))-sterol reductase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011503.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUC5, E9P929, P25340
    UniProtKB/TrEMBL
    A6ZUY1, B3LIM7, C7GK61, G2WE81, N1P5L7
    Conserved Domains (1) summary
    pfam01222
    Location:34 → 473
    ERG4_ERG24; Ergosterol biosynthesis ERG4/ERG24 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25340.2

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