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TIM21 Tim21p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852921, updated on 9-Dec-2024

Summary

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Official Symbol
TIM21
Official Full Name
Tim21p
Primary source
SGD:S000003265
Locus tag
YGR033C
See related
AllianceGenome:SGD:S000003265; FungiDB:YGR033C; VEuPathDB:YGR033C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in protein import into mitochondrial matrix. Located in mitochondrion. Part of TIM23 mitochondrial import inner membrane translocase complex. Orthologous to human TIMM21 (translocase of inner mitochondrial membrane 21). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See TIM21 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (554248..554967, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Imo32p Neighboring gene Nag1p Neighboring gene 1,3-beta-glucan synthase GSC2 Neighboring gene ribosomal 60S subunit protein L26B Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Conformational ensemble of an intrinsically flexible loop in mitochondrial import protein Tim21 studied by modeling and molecular dynamics simulations. Srivastava A, et al. Biochim Biophys Acta Gen Subj, 2020 Feb. PMID 31445064
  2. Crystal contact-free conformation of an intrinsically flexible loop in protein crystal: Tim21 as the case study. Bala S, et al. Biochim Biophys Acta Gen Subj, 2020 Feb. PMID 31449839
  3. The Tim21 binding domain connects the preprotein translocases of both mitochondrial membranes. Albrecht R, et al. EMBO Rep, 2006 Dec. PMID 17099692, Free PMC Article
  4. Mitochondrial protein sorting as a therapeutic target for ATP synthase disorders. Aiyar RS, et al. Nat Commun, 2014 Dec 18. PMID 25519239, Free PMC Article
  5. Stendomycin selectively inhibits TIM23-dependent mitochondrial protein import. Filipuzzi I, et al. Nat Chem Biol, 2017 Dec. PMID 28991239, Free PMC Article

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. analysis of a loop segment in Tim21, which is in close proximity of the binding site of Tim23, has different conformations in X-ray, NMR and new crystal contact-free space structures
    Title: Conformational ensemble of an intrinsically flexible loop in mitochondrial import protein Tim21 studied by modeling and molecular dynamics simulations.
  2. loop 2 of yeast Tim21 in the crystal contact-free space adopts a representative, dominant conformation in solution
    Title: Crystal contact-free conformation of an intrinsically flexible loop in protein crystal: Tim21 as the case study.
  3. Three Tim23 motifs bind to a single conserved pocket in Tim21.
    Title: Molecular basis of the dynamic structure of the TIM23 complex in the mitochondrial intermembrane space.
  4. The signal-driven release of Tim21 from Tim50 promotes recruitment of Pam17 and thus triggers formation of the motor-associated form of the TIM23 complex required for matrix transport.
    Title: Signal recognition initiates reorganization of the presequence translocase during protein import.
  5. Tim21 binds to the trans site of the TOM complex thus keeping the two translocases in close contact
    Title: Role of Tim21 in mitochondrial translocation contact sites.
  6. Tim21 interacts with the respiratory chain and promotes membrane-potential-dependent protein sorting into the inner mitochondrial membrane.
    Title: A role for Tim21 in membrane-potential-dependent preprotein sorting in mitochondria.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in protein import into mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
involved_in protein import into mitochondrial matrix IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of TIM23 mitochondrial import inner membrane translocase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TIM23 mitochondrial import inner membrane translocase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of TIM23 mitochondrial import inner membrane translocase complex IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Tim21p
NP_011547.3
  • Nonessential component of the TIM23 complex; interacts with the Translocase of the Outer Mitochondrial membrane (TOM complex) and with respiratory enzymes; may regulate the Translocase of the Inner Mitochondrial membrane (TIM23 complex) activity

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    554248..554967 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181162.3 → NP_011547.3  TPA: Tim21p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011547.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUG9, P53220, Q45U51
    UniProtKB/TrEMBL
    A6ZV21, B3LII7, B5VIZ2, C7GKA1, C8Z8S8, G2WEC3, N1P233
    Conserved Domains (1) summary
    pfam08294
    Location:67 → 219
    TIM21
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53220.1

Gene LinkOut

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