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MTE1 Mte1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852933, updated on 4-Jan-2025

Summary

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Official Symbol
MTE1
Official Full Name
Mte1p
Primary source
SGD:S000003274
Locus tag
YGR042W
See related
AllianceGenome:SGD:S000003274; FungiDB:YGR042W; VEuPathDB:YGR042W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables enzyme activator activity. Involved in negative regulation of telomere maintenance. Located in chromosome, telomeric region and site of double-strand break. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See MTE1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (579476..580291)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene mitogen-activated serine/threonine-protein kinase KSS1 Neighboring gene Bud9p Neighboring gene sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase NQM1 Neighboring gene Rme1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential regulation of the anti-crossover and replication fork regression activities of Mph1 by Mte1. Xue X, et al. Genes Dev, 2016 Mar 15. PMID 26966246, Free PMC Article
  2. Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance. Silva S, et al. Genes Dev, 2016 Mar 15. PMID 26966248, Free PMC Article
  3. The FANCM family Mph1 helicase localizes to the mitochondria and contributes to mtDNA stability. Bernal M, et al. DNA Repair (Amst), 2019 Oct. PMID 31569000
  4. A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Askree SH, et al. Proc Natl Acad Sci U S A, 2004 Jun 8. PMID 15161972, Free PMC Article
  5. Network Rewiring of Homologous Recombination Enzymes during Mitotic Proliferation and Meiosis. Wild P, et al. Mol Cell, 2019 Aug 22. PMID 31351878, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables enzyme activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of telomere maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome, telomeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in nucleus HDA PubMed 
located_in site of double-strand break IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Mte1p
NP_011556.1
  • hypothetical protein; involved in maintenance of proper telomere length; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; forms nuclear foci upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    579476..580291
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181171.1 → NP_011556.1  TPA: Mte1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011556.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUI0, P53227
    UniProtKB/TrEMBL
    B3LIH9, C7GXM8, C8Z8T8, N1P5Q6
    Conserved Domains (1) summary
    pfam10382
    Location:5 → 88
    DUF2439; Protein of unknown function (DUF2439)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53227.1

Gene LinkOut

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