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ART5 Art5p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852960, updated on 9-Dec-2024

Summary

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Official Symbol
ART5
Official Full Name
Art5p
Primary source
SGD:S000003300
Locus tag
YGR068C
See related
AllianceGenome:SGD:S000003300; FungiDB:YGR068C; VEuPathDB:YGR068C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables ubiquitin protein ligase binding activity. Predicted to be involved in ubiquitin-dependent endocytosis. Located in cytosol. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ART5 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (625324..627084, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Gid10p Neighboring gene uncharacterized protein Neighboring gene Rho family guanine nucleotide exchange factor ROM1 Neighboring gene Env11p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of yeast Art5 as a multicopy suppressor for the mitochondrial translocator maintenance protein Tam41. Harada Y, et al. Biochem Biophys Res Commun, 2010 Feb 5. PMID 20074554
  2. Deconstructing the genetic basis of spent sulphite liquor tolerance using deep sequencing of genome-shuffled yeast. Pinel D, et al. Biotechnol Biofuels, 2015. PMID 25866561, Free PMC Article
  3. Tam41 is a CDP-diacylglycerol synthase required for cardiolipin biosynthesis in mitochondria. Tamura Y, et al. Cell Metab, 2013 May 7. PMID 23623749, Free PMC Article
  4. Functional dissection of a HECT ubiquitin E3 ligase. Lu JY, et al. Mol Cell Proteomics, 2008 Jan. PMID 17951556, Free PMC Article
  5. Rsp5-dependent endocytosis and degradation of the arsenite transporter Acr3 requires its N-terminal acidic tail as an endocytic sorting signal and arrestin-related ubiquitin-ligase adaptors. Wawrzycka D, et al. Biochim Biophys Acta Biomembr, 2019 May 1. PMID 30776335

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein-macromolecule adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent endocytosis ISA
Inferred from Sequence Alignment
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Art5p
NP_011582.1
  • Protein proposed to regulate endocytosis of plasma membrane proteins; regulates by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane; SWAT-GFP and mCherry fusion proteins localize to the cytosol

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    625324..627084 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181197.1 → NP_011582.1  TPA: Art5p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011582.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUK2, P53244
    UniProtKB/TrEMBL
    A6ZV52, C8Z8W2, N1P5S5
    Conserved Domains (1) summary
    pfam02752
    Location:332 → 475
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53244.1

Gene LinkOut

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