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PHB1 prohibitin subunit PHB1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853033, updated on 4-Jan-2025

Summary

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Official Symbol
PHB1
Official Full Name
prohibitin subunit PHB1
Primary source
SGD:S000003364
Locus tag
YGR132C
See related
AllianceGenome:SGD:S000003364; FungiDB:YGR132C; VEuPathDB:YGR132C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in several processes, including inner mitochondrial membrane organization; mitochondrion inheritance; and protein folding. Located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in breast cancer and sporadic breast cancer. Orthologous to human PHB1 (prohibitin 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See PHB1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (755589..756452, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Fhn1p Neighboring gene E2 ubiquitin-protein ligase peroxin 4 Neighboring gene CCR4-NOT core subunit CAF130

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Loss of prohibitins, though it shortens the replicative life span of yeast cells undergoing division, does not shorten the chronological life span of G0-arrested cells. Piper PW, et al. Mech Ageing Dev, 2002 Feb. PMID 11744041
  2. A structure for the yeast prohibitin complex: Structure prediction and evidence from chemical crosslinking and mass spectrometry. Back JW, et al. Protein Sci, 2002 Oct. PMID 12237468, Free PMC Article
  3. Prohibitins act as a membrane-bound chaperone for the stabilization of mitochondrial proteins. Nijtmans LG, et al. EMBO J, 2000 Jun 1. PMID 10835343, Free PMC Article
  4. The shortened replicative life span of prohibitin mutants of yeast appears to be due to defective mitochondrial segregation in old mother cells. Piper PW, et al. Aging Cell, 2002 Dec. PMID 12882345
  5. Prohibitins and Ras2 protein cooperate in the maintenance of mitochondrial function during yeast aging. Kirchman PA, et al. Acta Biochim Pol, 2003. PMID 14739993

See all (88) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in inner mitochondrial membrane organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in inner mitochondrial membrane organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrion inheritance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of proteolysis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein folding IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
prohibitin subunit PHB1
NP_011648.3
  • Subunit of the prohibitin complex (Phb1p-Phb2p); prohibitin is a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation; prohibitin deficiency induces a mitochondrial unfolded protein response (mtUPR)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    755589..756452 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181261.3 → NP_011648.3  TPA: prohibitin subunit PHB1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011648.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUR4, P40961
    UniProtKB/TrEMBL
    A6ZUE6, B3LI96, B5VJ77, C7GUG3, C8Z925, G2WEL4, N1P430
    Conserved Domains (1) summary
    cd03401
    Location:29 → 223
    SPFH_prohibitin; Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40961.2

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