U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

GTO1 omega-class glutathione transferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 853058, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
GTO1
Official Full Name
omega-class glutathione transferase
Primary source
SGD:S000003386
Locus tag
YGR154C
See related
AllianceGenome:SGD:S000003386; FungiDB:YGR154C; VEuPathDB:YGR154C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables glutathione transferase activity. Predicted to be involved in glutathione metabolic process. Located in peroxisome. [provided by Alliance of Genome Resources, Jan 2025]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See GTO1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (796798..797868, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Ras family GTPase RSR1 Neighboring gene uncharacterized protein Neighboring gene cystathionine beta-synthase CYS4 Neighboring gene cleavage polyadenylation factor subunit PTI1

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Evolutionary relationships between Saccharomyces cerevisiae and other fungal species as determined from genome comparisons. Herrero E. Rev Iberoam Micol, 2005 Dec. PMID 16499414
  2. Saccharomyces cerevisiae cells have three Omega class glutathione S-transferases acting as 1-Cys thiol transferases. Garcerá A, et al. Biochem J, 2006 Sep 1. PMID 16709151, Free PMC Article
  3. A peroxisomal glutathione transferase of Saccharomyces cerevisiae is functionally related to sulfur amino acid metabolism. Barreto L, et al. Eukaryot Cell, 2006 Oct. PMID 16936141, Free PMC Article
  4. Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein. Willingham S, et al. Science, 2003 Dec 5. PMID 14657499
  5. Association of yeast Upf1p with direct substrates of the NMD pathway. Johansson MJ, et al. Proc Natl Acad Sci U S A, 2007 Dec 26. PMID 18087042, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Gto1 is located at the peroxisomes in S. cerevisiae, where it is involved in transulfuration of cysteine into homocysteine, and requires a conserved cysteine residue for its biological activity.
    Title: A peroxisomal glutathione transferase of Saccharomyces cerevisiae is functionally related to sulfur amino acid metabolism.
  2. act as 1-Cys thiol transferases
    Title: Saccharomyces cerevisiae cells have three Omega class glutathione S-transferases acting as 1-Cys thiol transferases.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables glutathione dehydrogenase (ascorbate) activity IEA
Inferred from Electronic Annotation
more info
  
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutathione transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glutathione transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
  
involved_in glutathione metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
omega-class glutathione transferase
NP_011670.3
  • Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    796798..797868 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181283.3 → NP_011670.3  TPA: omega-class glutathione transferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011670.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUT4, P48239
    UniProtKB/TrEMBL
    G2WEN4, N1P446
    Conserved Domains (1) summary
    COG0435
    Location:1 → 356
    ECM4; Glutathionyl-hydroquinone reductase [Energy production and conversion]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P48239.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools