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CLC1 Clc1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853077, updated on 4-Jan-2025

Summary

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Official Symbol
CLC1
Official Full Name
Clc1p
Primary source
SGD:S000003399
Locus tag
YGR167W
See related
AllianceGenome:SGD:S000003399; FungiDB:YGR167W; VEuPathDB:YGR167W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SCD4
Summary
Predicted to enable clathrin heavy chain binding activity. Involved in endocytosis; positive regulation of endocytosis; and protein-containing complex assembly. Located in trans-Golgi network. Orthologous to human CLTA (clathrin light chain A) and CLTB (clathrin light chain B). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See CLC1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (832456..833157)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene mitochondrial 37S ribosomal protein MRPS35 Neighboring gene Trs65p Neighboring gene Pex35p Neighboring gene pseudouridine synthase PUS6

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Yeast clathrin has a distinctive light chain that is important for cell growth. Silveira LA, et al. J Cell Biol, 1990 Oct. PMID 2211819, Free PMC Article
  2. A novel structural model for regulation of clathrin function. Pishvaee B, et al. EMBO J, 1997 May 1. PMID 9171338, Free PMC Article
  3. Creating a chimeric clathrin heavy chain that functions independently of yeast clathrin light chain. Boettner DR, et al. Traffic, 2016 Jul. PMID 27062026, Free PMC Article
  4. A modulatory role for clathrin light chain phosphorylation in Golgi membrane protein localization during vegetative growth and during the mating response of Saccharomyces cerevisiae. Chu DS, et al. Mol Biol Cell, 1999 Mar. PMID 10069813, Free PMC Article
  5. Novel functions of clathrin light chains: clathrin heavy chain trimerization is defective in light chain-deficient yeast. Huang KM, et al. J Cell Sci, 1997 Apr. PMID 9133677

See all (79) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CLC directs endocytic progression by pruning the Sla2-actin attachments in the clathrin lattice, providing direction for membrane internalization.
    Title: Clathrin light chain directs endocytosis by influencing the binding of the yeast Hip1R homologue, Sla2, to F-actin.
  2. We propose that LC binding to Sla2p positively regulates Sla2p for efficient endocytic vesicle formation.
    Title: Novel function of clathrin light chain in promoting endocytic vesicle formation.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables clathrin heavy chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
  
enables structural molecule activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in clathrin-dependent endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytosis IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein-containing complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of clathrin coat of coated pit IEA
Inferred from Electronic Annotation
more info
  
part_of clathrin coat of trans-Golgi network vesicle IEA
Inferred from Electronic Annotation
more info
  
part_of clathrin vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of clathrin vesicle coat TAS
Traceable Author Statement
more info
 PubMed 
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Clc1p
NP_011683.3
  • Clathrin light chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; regulates endocytic progression; thought to regulate clathrin function; the clathrin triskelion is a trimeric molecule composed of three heavy chains that radiate from a vertex and three light chains which bind noncovalently near the vertex of the triskelion

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    832456..833157
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181296.3 → NP_011683.3  TPA: Clc1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011683.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUV0, P17891
    UniProtKB/TrEMBL
    A6ZUH7, B3LI64, B5VJB1, C7GQ74, N1P3U4
    Conserved Domains (1) summary
    pfam01086
    Location:1 → 227
    Clathrin_lg_ch; Clathrin light chain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17891.1

Gene LinkOut

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