CRH1 transglycosylase [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: CRH1
Official Full Name: transglycosylase
Primary source: SGD:S000003421
Locus tag: YGR189C
See related: AllianceGenome:SGD:S000003421; FungiDB:YGR189C; VEuPathDB:YGR189C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables glycosyltransferase activity. Involved in chitin metabolic process and fungal-type cell wall organization. Located in fungal-type cell wall and incipient cellular bud site. [provided by Alliance of Genome Resources, Jan 2025]
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Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

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ssays of heterologously expressed transglycosylases ScGas1, ScCrh1, and ScCrh2 from the yeast Saccharomyces cerevisiae, CaPhr1 and CaPhr2 from Candida albicans, and of a plant xyloglucan endotransglycosylase (XET) are demonstrated.
Title: Two Variants of a High-Throughput Fluorescent Microplate Assay of Polysaccharide Endotransglycosylases.
catalytic properties of Crh1 yeast cell wall transglycosylases
Title: A novel fluorescence assay and catalytic properties of Crh1 and Crh2 yeast cell wall transglycosylases.
Crh1 and Crh2 catalyze the transfer of chitin to both beta(1-3)- and beta(1-6)glucan in cell wall.
Title: Two novel techniques for determination of polysaccharide cross-links show that Crh1p and Crh2p attach chitin to both beta(1-6)- and beta(1-3)glucan in the Saccharomyces cerevisiae cell wall.
Crh1p and Crh2p act as transglycosylases in vivo and in vitro
Title: Assembly of the yeast cell wall. Crh1p and Crh2p act as transglycosylases in vivo and in vitro.
Study indicates that Crh1p and Crh2p, homologues of glycosyltransferases, ferry chitin chains from chitin synthase III to beta(1-6)glucan.
Title: Crh1p and Crh2p are required for the cross-linking of chitin to beta(1-6)glucan in the Saccharomyces cerevisiae cell wall.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables glycosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glycosyltransferase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables glycosyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables hydrolase activity, acting on glycosyl bonds	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, hydrolyzing O-glycosyl compounds	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in cell wall organization	IEA Inferred from Electronic Annotation more info
involved_in chitin metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in chitin metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in chitin metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fungal-type cell wall organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in fungal-type cell wall organization	IEA Inferred from Electronic Annotation more info
involved_in fungal-type cell wall organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in fungal-type cell wall organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell periphery	HDA more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in fungal-type cell wall	IBA Inferred from Biological aspect of Ancestor more info
located_in fungal-type cell wall	IDA Inferred from Direct Assay more info	PubMed
located_in incipient cellular bud site	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

NP_011705.1

Chitin transglycosylase; functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress

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