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YPP1 Ypp1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853112, updated on 9-Dec-2024

Summary

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Official Symbol
YPP1
Official Full Name
Ypp1p
Primary source
SGD:S000003430
Locus tag
YGR198W
See related
AllianceGenome:SGD:S000003430; FungiDB:YGR198W; VEuPathDB:YGR198W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in protein localization to plasma membrane; protein targeting to vacuole; and receptor-mediated endocytosis. Located in several cellular components, including actin cortical patch; cytosol; and endosome. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See YPP1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (894693..897146)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Fyv8p Neighboring gene Sng1p Neighboring gene dolichyl-phosphate-mannose-protein mannosyltransferase PMT6 Neighboring gene Elongator subunit ELP2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural insights into assembly and regulation of the plasma membrane phosphatidylinositol 4-kinase complex. Wu X, et al. Dev Cell, 2014 Jan 13. PMID 24360784, Free PMC Article
  2. Ypp1/YGR198w plays an essential role in phosphoinositide signalling at the plasma membrane. Zhai C, et al. Biochem J, 2008 Nov 1. PMID 18601652
  3. Assembly of the PtdIns 4-kinase Stt4 complex at the plasma membrane requires Ypp1 and Efr3. Baird D, et al. J Cell Biol, 2008 Dec 15. PMID 19075114, Free PMC Article
  4. The deletion of six ORFs of unknown function from Saccharomyces cerevisiae chromosome VII reveals two essential genes: YGR195w and YGR198w. Rodriguez-Peña JM, et al. Yeast, 1998 Jun 30. PMID 9818723
  5. A heat-sensitive Osh protein controls PI4P polarity. Omnus DJ, et al. BMC Biol, 2020 Mar 13. PMID 32169085, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ypp1 and Efr3 are required for the formation and architecture of Stt4 PIK patches and ultimately plasma membrane-based PtdIns4P signaling.
    Title: Assembly of the PtdIns 4-kinase Stt4 complex at the plasma membrane requires Ypp1 and Efr3.
  2. a role for Ypp1 in Stt4-dependent events at the plasma membrane, as opposed to a general role in overall metabolism of phosphatidylinositol 4-phosphate.
    Title: Ypp1/YGR198w plays an essential role in phosphoinositide signalling at the plasma membrane.
  3. YPP1 mediates the trafficking of A30P to the vacuole via the endocytic pathway.
    Title: YGR198w (YPP1) targets A30P alpha-synuclein to the vacuole for degradation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein targeting to vacuole IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein targeting to vacuole IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in receptor-mediated endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in actin cortical patch IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in cytosol HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in plasma membrane HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ypp1p
NP_011714.3
  • Cargo-transport protein involved in endocytosis; interacts with phosphatidylinositol-4-kinase Stt4p; is required, along with Efr3p, for the assembly and recruitment of multiple copies of the kinase into phosphoinositide kinase (PIK) patches at the plasma membrane; positively regulates Stt4p; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    894693..897146
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181327.3 → NP_011714.3  TPA: Ypp1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011714.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUY0, P46951
    UniProtKB/TrEMBL
    B5VJE1, C8Z991, N1P9Y1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P46951.1

Gene LinkOut

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