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SER2 phosphoserine phosphatase [ Saccharomyces cerevisiae S288C ]

Gene ID: 853122, updated on 9-Dec-2024

Summary

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Official Symbol
SER2
Official Full Name
phosphoserine phosphatase
Primary source
SGD:S000003440
Locus tag
YGR208W
See related
AllianceGenome:SGD:S000003440; FungiDB:YGR208W; VEuPathDB:YGR208W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables L-phosphoserine phosphatase activity. Involved in L-serine biosynthetic process. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in PSPH deficiency. Orthologous to human PSPH (phosphoserine phosphatase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SER2 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (911883..912812)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene ubiquitin-binding ESCRT-I subunit protein MVB12 Neighboring gene Cir1p Neighboring gene thioredoxin TRX2 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. O-phosphoserine phosphatase from Baker's yeast. SCHRAMM M. J Biol Chem, 1958 Nov. PMID 13598753
  2. Genetic and physiological control of serine and glycine biosynthesis in Saccharomyces. Ulane R, et al. J Bacteriol, 1972 Jan. PMID 4333378, Free PMC Article
  3. Cloning and characterization of two novel chloroplastic glycerol-3-phosphate dehydrogenases from Dunaliella viridis. He Y, et al. Plant Mol Biol, 2009 Sep. PMID 19551475
  4. Genetic analysis of serine biosynthesis and glucose repression in yeast. Melcher K, et al. Curr Genet, 1992 Apr. PMID 1326413
  5. RNA Pol II Dynamics Modulate Co-transcriptional Chromatin Modification, CTD Phosphorylation, and Transcriptional Direction. Fong N, et al. Mol Cell, 2017 May 18. PMID 28506463, Free PMC Article

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables L-phosphoserine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-phosphoserine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables L-phosphoserine phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-serine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-serine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in L-serine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
phosphoserine phosphatase
NP_011724.1
  • Phosphoserine phosphatase of the phosphoglycerate pathway; involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    911883..912812
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181337.1 → NP_011724.1  TPA: phosphoserine phosphatase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011724.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUZ1, P42941
    UniProtKB/TrEMBL
    A6ZUL9, B3LI28, C7GRP1, C8Z9A1, G2WET7, N1P4A4
    Conserved Domains (1) summary
    TIGR00338
    Location:78 → 298
    serB; phosphoserine phosphatase SerB
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P42941.1

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