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PHO81 Pho81p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853148, updated on 9-Dec-2024

Summary

Official Symbol
PHO81
Official Full Name
Pho81p
Primary source
SGD:S000003465
Locus tag
YGR233C
See related
AllianceGenome:SGD:S000003465; FungiDB:YGR233C; VEuPathDB:YGR233C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
VAC6
Summary
Enables cyclin-dependent protein serine/threonine kinase inhibitor activity. Involved in cellular response to phosphate starvation and phosphate-containing compound metabolic process. Located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See PHO81 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (954674..958210, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene prohibitin subunit PHB2 Neighboring gene Nas6p Neighboring gene flavohemoglobin Neighboring gene Mic26p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
Pho81p
NP_011749.3
  • Cyclin-dependent kinase (CDK) inhibitor; regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p; relative distribution to the nucleus increases upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    954674..958210 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181362.3NP_011749.3  TPA: Pho81p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011749.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VV13, P17442, Q06887
    UniProtKB/TrEMBL
    G2WEV9, N1P9Y8
    Conserved Domains (5) summary
    PHA02875
    Location:466650
    PHA02875; ankyrin repeat protein; Provisional
    cd08578
    Location:8751172
    GDPD_NUC-2_fungi; Putative glycerophosphodiester phosphodiesterase domain of ankyrin repeat protein NUC-2 and similar proteins
    cd14483
    Location:2159
    SPX_PHO81_NUC-2_like; SPX domain of Pho81, NUC-2, and similar proteins
    sd00045
    Location:561588
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:561647
    Ank_2; Ankyrin repeats (3 copies)