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TNA1 Tna1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853175, updated on 9-Dec-2024

Summary

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Official Symbol
TNA1
Official Full Name
Tna1p
Primary source
SGD:S000003492
Locus tag
YGR260W
See related
AllianceGenome:SGD:S000003492; FungiDB:YGR260W; VEuPathDB:YGR260W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables carboxylic acid transmembrane transporter activity. Involved in quinolinic acid transmembrane transport. Located in cell periphery; fungal-type vacuole; and mitochondrion. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 25; gout; porokeratosis; and sialuria. Orthologous to several human genes including SLC17A1 (solute carrier family 17 member 1); SLC17A2 (solute carrier family 17 member 2); and SLC17A3 (solute carrier family 17 member 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See TNA1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (1012485..1014089)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Mtm1p Neighboring gene ssDNA endodeoxyribonuclease RAD2 Neighboring gene Apl6p Neighboring gene serine/threonine protein kinase BUD32

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transcription of the yeast TNA1 gene is not only regulated by nicotinate but also by p-aminobenzoate. Klebl F, et al. FEBS Lett, 2000 Sep 8. PMID 10984621
  2. Secretion of quinolinic acid, an intermediate in the kynurenine pathway, for utilization in NAD+ biosynthesis in the yeast Saccharomyces cerevisiae. Ohashi K, et al. Eukaryot Cell, 2013 May. PMID 23457190, Free PMC Article
  3. Unified inventory of established and putative transporters encoded within the complete genome of Saccharomyces cerevisiae. Paulsen IT, et al. FEBS Lett, 1998 Jun 23. PMID 9678606
  4. Nrt1 and Tna1-independent export of NAD+ precursor vitamins promotes NAD+ homeostasis and allows engineering of vitamin production. Belenky P, et al. PLoS One, 2011 May 11. PMID 21589930, Free PMC Article
  5. Transcriptional regulation of the Saccharomyces cerevisiae DAL5 gene family and identification of the high affinity nicotinic acid permease TNA1 (YGR260w). Llorente B, et al. FEBS Lett, 2000 Jun 23. PMID 10869563

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables carboxylic acid transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carboxylic acid transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in quinolinic acid transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in cortical endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in fungal-type vacuole HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Tna1p
NP_011776.1
  • High affinity nicotinic acid plasma membrane permease; responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    1012485..1014089
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181389.1 → NP_011776.1  TPA: Tna1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011776.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VV39, P53322
    UniProtKB/TrEMBL
    B3LHY2, B5VJK2, N1P2P5
    Conserved Domains (1) summary
    cd17327
    Location:87 → 490
    MFS_FEN2_like; Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53322.1

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