MES1 methionine--tRNA ligase MES1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: MES1
Official Full Name: methionine--tRNA ligase MES1
Primary source: SGD:S000003496
Locus tag: YGR264C
See related: AllianceGenome:SGD:S000003496; FungiDB:YGR264C; VEuPathDB:YGR264C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables methionine-tRNA ligase activity and sequence-specific mRNA binding activity. Involved in methionyl-tRNA aminoacylation. Located in cytoplasmic stress granule. Part of methionyl glutamyl tRNA synthetase complex. Used to study Charcot-Marie-Tooth disease axonal type 2U and pulmonary alveolar proteinosis. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2U; hereditary spastic paraplegia 70; and trichothiodystrophy. Orthologous to human MARS1 (methionyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See MES1 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (1019598..1021853, complement)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

mutations that abolish the interaction of methionyl-tRNA synthetase with Arc1p cause entry of the enzyme into the nucleus, proving that complex association regulates its subcellular distribution.
Title: Molecular determinants of the yeast Arc1p-aminoacyl-tRNA synthetase complex assembly.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables aminoacyl-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables methionine-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables methionine-tRNA ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables methionine-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in methionyl-tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in methionyl-tRNA aminoacylation	IDA Inferred from Direct Assay more info	PubMed
involved_in methionyl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info
involved_in translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of aminoacyl-tRNA synthetase multienzyme complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
part_of methionyl glutamyl tRNA synthetase complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: methionine--tRNA ligase MES1

NP_011780.3

EC 6.1.1.10

Methionyl-tRNA synthetase; forms a complex with Gus1p, a glutamyl-tRNA synthetase, and Arc1p, which increases the catalytic efficiency of both synthetases; involved in the nuclear export of tRNAs; mutations in human ortholog MARS is associated with pediatric pulmonary alveolar proteinosis, interstitial lung and liver disease, and Charcot-Marie-Tooth disease; human MARS gene can complement the yeast null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

1019598..1021853 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181393.3 → NP_011780.3 TPA: methionine--tRNA ligase MES1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011780.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VV43, P00958

UniProtKB/TrEMBL

A6ZUS2, B3LHX8, C8Z9F6, N1P448

Conserved Domains (2) summary

PLN02610
Location:190 → 750

PLN02610; probable methionyl-tRNA synthetase

pfam09635
Location:11 → 132

MetRS-N; MetRS-N binding domain