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LAA1 Laa1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853223, updated on 4-Jan-2025

Summary

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Official Symbol
LAA1
Official Full Name
Laa1p
Primary source
SGD:S000003743
Locus tag
YJL207C
See related
AllianceGenome:SGD:S000003743; FungiDB:YJL207C; VEuPathDB:YJL207C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in protein localization and retrograde transport, endosome to Golgi. Acts upstream of or within clathrin-coated vesicle cargo loading, AP-1-mediated. Located in clathrin-coated vesicle. Orthologous to human HEATR5A (HEAT repeat containing 5A) and HEATR5B (HEAT repeat containing 5B). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See LAA1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (41389..47433, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Cbp1p Neighboring gene ribonuclease Neighboring gene uncharacterized protein Neighboring gene Nce101p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Adaptor protein complex-1 (AP-1) is recruited by the HEATR5 protein Laa1 and its co-factor Laa2 in yeast. Zysnarski CJ, et al. J Biol Chem, 2019 Jan 25. PMID 30523155, Free PMC Article
  2. Laa1p, a conserved AP-1 accessory protein important for AP-1 localization in yeast. Fernández GE, et al. Mol Biol Cell, 2006 Jul. PMID 16687571, Free PMC Article
  3. Numerous Post-translational Modifications of RNA Polymerase II Subunit Rpb4/7 Link Transcription to Post-transcriptional Mechanisms. Richard S, et al. Cell Rep, 2021 Jan 12. PMID 33440147
  4. Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes. Fleischer TC, et al. Genes Dev, 2006 May 15. PMID 16702403, Free PMC Article
  5. The GET pathway is a major bottleneck for maintaining proteostasis in Saccharomyces cerevisiae. Josefson R, et al. Sci Rep, 2023 Jun 7. PMID 37286562, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fast-evolving cofactors regulate the role of HEATR5 complexes in intra-Golgi trafficking.
    Title: Fast-evolving cofactors regulate the role of HEATR5 complexes in intra-Golgi trafficking.
  2. results indicate that Laa2 mediates the interaction between Laa1 and AP-1 and reveal that this interaction promotes the stable association of AP-1 with membranes in yeast
    Title: Adaptor protein complex-1 (AP-1) is recruited by the HEATR5 protein Laa1 and its co-factor Laa2 in yeast.
  3. These results identify Laa1p as a new determinant of AP-1 localization, suggesting a model in which Laa1p and Arf cooperate to direct stable association of AP-1 with appropriate intracellular membranes.
    Title: Laa1p, a conserved AP-1 accessory protein important for AP-1 localization in yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within clathrin-coated vesicle cargo loading, AP-1-mediated IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde transport, endosome to Golgi IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in retrograde transport, endosome to Golgi IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in clathrin-coated vesicle HDA PubMed 
located_in clathrin-coated vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in endocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Laa1p
NP_012328.1
  • AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    41389..47433 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181640.1 → NP_012328.1  TPA: Laa1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012328.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVY7, P39526
    UniProtKB/TrEMBL
    C8ZB13
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39526.1

Gene LinkOut

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