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GON7 chromatin DNA-binding EKC/KEOPS complex subunit GON7 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853255, updated on 4-Jan-2025

Summary

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Official Symbol
GON7
Official Full Name
chromatin DNA-binding EKC/KEOPS complex subunit GON7
Primary source
SGD:S000003720
Locus tag
YJL184W
See related
AllianceGenome:SGD:S000003720; FungiDB:YJL184W; VEuPathDB:YJL184W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
LDB6; PCC2
Summary
Enables chromatin DNA binding activity. Involved in cell wall mannoprotein biosynthetic process; positive regulation of transcription by RNA polymerase II; and telomere maintenance via recombination. Located in chromatin. Part of EKC/KEOPS complex. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See GON7 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (83448..83819)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene alpha-1,2-mannosyltransferase MNN5 Neighboring gene Atg36p Neighboring gene alpha-1,6-mannosyltransferase Neighboring gene Rbh1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystal structures of the Gon7/Pcc1 and Bud32/Cgi121 complexes provide a model for the complete yeast KEOPS complex. Zhang W, et al. Nucleic Acids Res, 2015 Mar 31. PMID 25735745, Free PMC Article
  2. Structural and functional characterization of KEOPS dimerization by Pcc1 and its role in t6A biosynthesis. Wan LC, et al. Nucleic Acids Res, 2016 Aug 19. PMID 27302132, Free PMC Article
  3. Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system. Wan LC, et al. Nucleic Acids Res, 2013 Jul. PMID 23620299, Free PMC Article
  4. Cell polarity in Saccharomyces cerevisiae depends on proper localization of the Bud9 landmark protein by the EKC/KEOPS complex. Kato Y, et al. Genetics, 2011 Aug. PMID 21625000, Free PMC Article
  5. The highly conserved KEOPS/EKC complex is essential for a universal tRNA modification, t6A. Srinivasan M, et al. EMBO J, 2011 Mar 2. PMID 21183954, Free PMC Article

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We found that Gon7 forms a stable heterodimer with Pcc1 and report the crystal structure of the Pcc1-Gon7 heterodimer.
    Title: Crystal structures of the Gon7/Pcc1 and Bud32/Cgi121 complexes provide a model for the complete yeast KEOPS complex.
  2. EKC/KEOPS complex is specifically involved in the regulation of Bud9p localization downstream of Rax1p/Rax2p.
    Title: Cell polarity in Saccharomyces cerevisiae depends on proper localization of the Bud9 landmark protein by the EKC/KEOPS complex.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables chromatin DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell wall mannoprotein biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in telomere maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomere maintenance via recombination IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of EKC/KEOPS complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
chromatin DNA-binding EKC/KEOPS complex subunit GON7
NP_012351.1
  • Component of the EKC/KEOPS protein complex; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription; implicated in osmotic stress response; other complex members are Kae1p, Cgi121p, Pcc1p, and Bud32p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    83448..83819
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181617.1 → NP_012351.1  TPA: chromatin DNA-binding EKC/KEOPS complex subunit GON7 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012351.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VW06, P46984
    UniProtKB/TrEMBL
    A6ZQF1, B3LPU2, C7GS09, C8ZB35, G2WGJ2, N1P1V7
    Conserved Domains (1) summary
    pfam08738
    Location:4 → 110
    Gon7; Gon7 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P46984.1

Gene LinkOut

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