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SWI3 Swi3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853264, updated on 9-Dec-2024

Summary

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Official Symbol
SWI3
Official Full Name
Swi3p
Primary source
SGD:S000003712
Locus tag
YJL176C
See related
AllianceGenome:SGD:S000003712; FungiDB:YJL176C; VEuPathDB:YJL176C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
HAF2; TYE2
Summary
Enables DNA binding activity and histone binding activity. Involved in carbon catabolite activation of transcription from RNA polymerase II promoter; chromatin remodeling; and positive regulation of mating type switching. Located in cytosol and nucleus. Part of SWI/SNF complex. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 8 and hydrocephalus. Orthologous to human SMARCC1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1) and SMARCC2 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SWI3 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (92053..94530, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Atg27p Neighboring gene ribosomal 60S subunit protein L17B Neighboring gene Kre9p Neighboring gene Rfa3p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Roles of SWI1, SWI2, and SWI3 proteins for transcriptional enhancement by steroid receptors. Yoshinaga SK, et al. Science, 1992 Dec 4. PMID 1360703
  2. Isolation of the TYE2 gene reveals its identity to SWI3 encoding a general transcription factor in Saccharomyces cerevisiae. Löhning C, et al. Curr Genet, 1993 Sep. PMID 8221926
  3. N-terminal deletion of Swi3 created by the deletion of a dubious ORF YJL175W mitigates protein burden effect in S. cerevisiae. Saeki N, et al. Sci Rep, 2020 Jun 11. PMID 32528012, Free PMC Article
  4. Catalytic activity of the yeast SWI/SNF complex on reconstituted nucleosome arrays. Logie C, et al. EMBO J, 1997 Nov 17. PMID 9362491, Free PMC Article
  5. Structure and function of the SWIRM domain, a conserved protein module found in chromatin regulatory complexes. Da G, et al. Proc Natl Acad Sci U S A, 2006 Feb 14. PMID 16461455, Free PMC Article

See all (146) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminal deletion of Swi3 created by the deletion of a dubious ORF YJL175W mitigates protein burden effect in S. cerevisiae.
    Title: N-terminal deletion of Swi3 created by the deletion of a dubious ORF YJL175W mitigates protein burden effect in S. cerevisiae.
  2. Structure of the yeast Swi/Snf complex in a nucleosome free state.
    Title: Structure of the yeast Swi/Snf complex in a nucleosome free state.
  3. our data showed that Swi3 strongly affects haem/oxygen-dependent activation of respiration gene promoters whereas Swi2 affects only the basal, haem-independent activities of these promoters. using computational analysis and RNAi knockdown, we showed that the mammalian Swi3 BAF155 and BAF170 regulate respiration in HeLa cells.
    Title: The Swi3 protein plays a unique role in regulating respiration in eukaryotes.
  4. Swi3p controls SWI/SNF assembly and ATP-dependent H2A-H2B displacement.
    Title: Swi3p controls SWI/SNF assembly and ATP-dependent H2A-H2B displacement.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of mating type switching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of SWI/SNF complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SWI/SNF complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SWI/SNF complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Swi3p
NP_012359.1
  • Subunit of the SWI/SNF chromatin remodeling complex; SWI/SNF regulates transcription by remodeling chromosomes; contains SANT domain that is required for SWI/SNF assembly; is essential for displacement of histone H2A-H2B dimers during ATP-dependent remodeling; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; relocates to the cytosol under hypoxic conditions

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    92053..94530 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181609.1 → NP_012359.1  TPA: Swi3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012359.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VW13, P32591
    UniProtKB/TrEMBL
    G2WGJ9
    Conserved Domains (1) summary
    COG5259
    Location:253 → 825
    RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32591.1

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