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MRS3 Fe(2+) transporter [ Saccharomyces cerevisiae S288C ]

Gene ID: 853308, updated on 9-Dec-2024

Summary

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Official Symbol
MRS3
Official Full Name
Fe(2+) transporter
Primary source
SGD:S000003669
Locus tag
YJL133W
See related
AllianceGenome:SGD:S000003669; FungiDB:YJL133W; VEuPathDB:YJL133W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables iron ion transmembrane transporter activity. Involved in iron import into the mitochondrion. Located in mitochondrion. Orthologous to human SLC25A28 (solute carrier family 25 member 28) and SLC25A37 (solute carrier family 25 member 37). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See MRS3 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (160619..161563)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene sphinganine kinase LCB3 Neighboring gene Dpi8p Neighboring gene uncharacterized protein Neighboring gene Aim23p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nuclear suppression of a mitochondrial RNA splice defect: nucleotide sequence and disruption of the MRS3 gene. Schmidt C, et al. Mol Gen Genet, 1987 Nov. PMID 2448588
  2. MRS3 and MRS4, two suppressors of mtRNA splicing defects in yeast, are new members of the mitochondrial carrier family. Wiesenberger G, et al. J Mol Biol, 1991 Jan 5. PMID 1703236
  3. Recovery of mrs3Δmrs4Δ Saccharomyces cerevisiae Cells under Iron-Sufficient Conditions and the Role of Fe(580). Moore MJ, et al. Biochemistry, 2018 Feb 6. PMID 29228768, Free PMC Article
  4. A specific role of the yeast mitochondrial carriers MRS3/4p in mitochondrial iron acquisition under iron-limiting conditions. Mühlenhoff U, et al. J Biol Chem, 2003 Oct 17. PMID 12902335
  5. The yeast mitochondrial carrier proteins Mrs3p/Mrs4p mediate iron transport across the inner mitochondrial membrane. Froschauer EM, et al. Biochim Biophys Acta, 2009 May. PMID 19285482

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Three highly conserved histidine residues are important for Mrs3p function and mitochondrial iron transport; Mrs (mitochondrial RNA splicing (Mrs)3p and Mrs4p are inserted into liposomes.
    Title: Three conserved histidine residues contribute to mitochondrial iron transport through mitoferrins.
  2. Inner mitochondrial membrane vesicles (SMPs) from the double deletion strain mrs3/4Delta failed to show a rapid Fe(2+) uptake, while SMPs from cells overproducing Mrs3/4p exhibited increased Fe(2+) uptake rates.
    Title: The yeast mitochondrial carrier proteins Mrs3p/Mrs4p mediate iron transport across the inner mitochondrial membrane.
  3. defective heme formation in mutants, with a markedly more severe defect in the DeltaDeltaDelta than in the individual Deltamrs3/4 or Deltayfh1 mutants
    Title: Frataxin and mitochondrial carrier proteins, Mrs3p and Mrs4p, cooperate in providing iron for heme synthesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ferrous iron transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables iron ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables iron ion transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in iron import into the mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in iron import into the mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in iron import into the mitochondrion IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Fe(2+) transporter
NP_012402.1
  • Iron transporter, mediates Fe2+ transport across inner mito membrane; mitochondrial carrier family member; active under low-iron conditions; may transport other cations; MRS3 has a paralog, MRS4, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    160619..161563
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181566.1 → NP_012402.1  TPA: Fe(2+) transporter [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012402.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VW52, P10566
    UniProtKB/TrEMBL
    A6ZQJ7, B3LPY5, B5VL44, C7GPZ6, C8ZB85, G2WGN8, N1P0H5
    Conserved Domains (2) summary
    PTZ00168
    Location:34 → 251
    PTZ00168; mitochondrial carrier protein; Provisional
    pfam00153
    Location:215 → 314
    Mito_carr; Mitochondrial carrier protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P10566.4

Gene LinkOut

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