U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

AIM23 Aim23p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853310, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
AIM23
Official Full Name
Aim23p
Primary source
SGD:S000003667
Locus tag
YJL131C
See related
AllianceGenome:SGD:S000003667; FungiDB:YJL131C; VEuPathDB:YJL131C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MIF3
Summary
Enables mitochondrial ribosome binding activity. Involved in mitochondrial translational initiation. Located in mitochondrion. [provided by Alliance of Genome Resources, Jan 2025]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See AIM23 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (164278..165348, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Fe(2+) transporter Neighboring gene uncharacterized protein Neighboring gene bifunctional carbamoylphosphate synthetase/aspartate transcarbamylase Neighboring gene Trk1p

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Evolutionary and genetic analyses of mitochondrial translation initiation factors identify the missing mitochondrial IF3 in S. cerevisiae. Atkinson GC, et al. Nucleic Acids Res, 2012 Jul. PMID 22457064, Free PMC Article
  2. Mitochondrial translation initiation machinery: conservation and diversification. Kuzmenko A, et al. Biochimie, 2014 May. PMID 23954798, Free PMC Article
  3. Aim-less translation: loss of Saccharomyces cerevisiae mitochondrial translation initiation factor mIF3/Aim23 leads to unbalanced protein synthesis. Kuzmenko A, et al. Sci Rep, 2016 Jan 5. PMID 26728900, Free PMC Article
  4. Biological and Evolutionary Significance of Terminal Extensions of Mitochondrial Translation Initiation Factor 3. Derbikova K, et al. Int J Mol Sci, 2018 Dec 4. PMID 30518034, Free PMC Article
  5. 60S dynamic state of bacterial ribosome is fixed by yeast mitochondrial initiation factor 3. Levitskii S, et al. PeerJ, 2018. PMID 30245939, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Yeast Mitochondrial Translation Initiation Factor 3 Interacts with Pet111p to Promote COX2 mRNA Translation.
    Title: Yeast Mitochondrial Translation Initiation Factor 3 Interacts with Pet111p to Promote COX2 mRNA Translation.
  2. Phylogenetic and in vivo complementation analyses reveal that an uncharacterized S. cerevisiae mitochondrial protein currently named Aim23p is a bona fide evolutionary and functional orthologue of mitochondrial IF3.
    Title: Evolutionary and genetic analyses of mitochondrial translation initiation factors identify the missing mitochondrial IF3 in S. cerevisiae.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables mitochondrial ribosome binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables translation initiation factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial translational initiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitochondrial translational initiation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Aim23p
NP_012404.1
  • Mitochondrial translation initiation factor 3 (IF3, mIF3); evolutionarily conserved; interacts with mitochondrial ribosomal small subunit; binds to E. coli ribosomes in vitro; null mutant displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    164278..165348 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181564.1 → NP_012404.1  TPA: Aim23p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012404.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZQJ9, B5VL46, C7GPZ8, C8ZB86, D6VW54, P47015
    UniProtKB/TrEMBL
    G2WGP0
    Conserved Domains (1) summary
    pfam14877
    Location:93 → 260
    mIF3; Mitochondrial translation initiation factor
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47015.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools