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CHM7 Chm7p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853398, updated on 4-Jan-2025

Summary

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Official Symbol
CHM7
Official Full Name
Chm7p
Primary source
SGD:S000003585
Locus tag
YJL049W
See related
AllianceGenome:SGD:S000003585; FungiDB:YJL049W; VEuPathDB:YJL049W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables phosphatidic acid binding activity. Involved in nuclear pore complex assembly. Is active in nuclear inner membrane. Orthologous to human CHMP7 (charged multivesicular body protein 7). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See CHM7 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (345973..347325)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Irc8p Neighboring gene ATP-dependent RNA helicase MTR4 Neighboring gene Ubx6p Neighboring gene uncharacterized protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Direct binding of ESCRT protein Chm7 to phosphatidic acid-rich membranes at nuclear envelope herniations. Thaller DJ, et al. J Cell Biol, 2021 Mar 1. PMID 33464310, Free PMC Article
  2. Comprehensive analysis of yeast ESCRT-III composition in single ESCRT-III deletion mutants. Heinzle C, et al. Biochem J, 2019 Jul 24. PMID 31273031
  3. ESCRT recruitment by the S. cerevisiae inner nuclear membrane protein Heh1 is regulated by Hub1-mediated alternative splicing. Capella M, et al. J Cell Sci, 2020 Dec 21. PMID 33262311
  4. Interactions in the ESCRT-III network of the yeast Saccharomyces cerevisiae. Brune T, et al. Curr Genet, 2019 Apr. PMID 30506264
  5. The ESCRT-III complex is required for nuclear pore complex sequestration and regulates gamete replicative lifespan in budding yeast meiosis. Koch BA, et al. Nucleus, 2020 Dec. PMID 32893723, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Chm7 recruitment to sites of nuclear pore complexes assembly is mediated by its ESCRT-II domain and the LAP2-emerin-MAN1 (LEM) family of integral inner nuclear membrane proteins, Heh1 and Heh2.
    Title: Chm7 and Heh1 collaborate to link nuclear pore complex quality control with nuclear envelope sealing.
  2. Chm7 performs a novel function at the endosomal reticulum as part of an alternative ESCRT-III complex
    Title: Evidence for a Nonendosomal Function of the Saccharomyces cerevisiae ESCRT-III-Like Protein Chm7.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables phosphatidic acid binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in late endosome to vacuole transport via multivesicular body sorting pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear pore complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vacuolar transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle budding from membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of ESCRT III complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
is_active_in multivesicular body IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nuclear inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Chm7p
NP_012486.3
  • Phosphatidic acid (PA)-binding nuclear envelope (NE)-specific ESCRT; homolog of human CHMP7, localizes to the endoplasmic reticulum presumably as part of ESCRT-III like complex

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    345973..347325
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181482.3 → NP_012486.3  TPA: Chm7p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012486.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWD4, P47048
    UniProtKB/TrEMBL
    G2WGW8, N1P0W5
    Conserved Domains (1) summary
    cl21588
    Location:247 → 381
    Snf7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47048.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.