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SDH9 succinate dehydrogenase SDH9 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853405, updated on 17-Dec-2024

Summary

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Official Symbol
SDH9
Official Full Name
succinate dehydrogenase SDH9
Primary source
SGD:S000003581
Locus tag
YJL045W
See related
AllianceGenome:SGD:S000003581; FungiDB:YJL045W; VEuPathDB:YJL045W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables succinate dehydrogenase (quinone) activity. Involved in cellular respiration. Located in mitochondrion. Human ortholog(s) of this gene implicated in Leigh disease; dilated cardiomyopathy 1GG; lung non-small cell carcinoma; mitochondrial complex II deficiency; and paraganglioma. Orthologous to human SDHA (succinate dehydrogenase complex flavoprotein subunit A). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SDH9 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (356024..357928)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene tRNA-Arg Neighboring gene tRNA-Asp Neighboring gene GTPase-activating protein GYP6 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Suppression of sdh1 mutations by the SDH1b gene of Saccharomyces cerevisiae. Colby G, et al. Yeast, 1998 Aug. PMID 9730279
  2. Effect of gene disruption of succinate dehydrogenase on succinate production in a sake yeast strain. Kubo Y, et al. J Biosci Bioeng, 2000. PMID 16232921
  3. The transcriptional activator Cat8p provides a major contribution to the reprogramming of carbon metabolism during the diauxic shift in Saccharomyces cerevisiae. Haurie V, et al. J Biol Chem, 2001 Jan 5. PMID 11024040
  4. The Crabtree Effect Shapes the Saccharomyces cerevisiae Lag Phase during the Switch between Different Carbon Sources. Perez-Samper G, et al. mBio, 2018 Oct 30. PMID 30377274, Free PMC Article
  5. Evaluation of genes involved in oxidative phosphorylation in yeast by developing a simple and rapid method to measure mitochondrial ATP synthetic activity. Ye X, et al. Microb Cell Fact, 2015 Apr 16. PMID 25880855, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables electron transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-CH group of donors IEA
Inferred from Electronic Annotation
more info
  
enables succinate dehydrogenase (quinone) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables succinate dehydrogenase (quinone) activity IEA
Inferred from Electronic Annotation
more info
  
enables succinate dehydrogenase (quinone) activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables succinate dehydrogenase (quinone) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables succinate dehydrogenase (quinone) activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular respiration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellular respiration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in electron transport chain IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial electron transport, succinate to ubiquinone IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
part_of respiratory chain complex II (succinate dehydrogenase) IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
succinate dehydrogenase SDH9
NP_012490.1
  • Minor succinate dehydrogenase isozyme; participates in oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner; YJL045W has a paralog, SDH1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    356024..357928
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181478.1 → NP_012490.1  TPA: succinate dehydrogenase SDH9 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012490.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWD9, P47052
    UniProtKB/TrEMBL
    B3LQ67, C7GSR5, G2WGX3, N1P369
    Conserved Domains (1) summary
    PTZ00139
    Location:5 → 634
    PTZ00139; Succinate dehydrogenase [ubiquinone] flavoprotein subunit; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47052.1

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