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VTC4 Vtc4p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853441, updated on 4-Jan-2025

Summary

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Official Symbol
VTC4
Official Full Name
Vtc4p
Primary source
SGD:S000003549
Locus tag
YJL012C
See related
AllianceGenome:SGD:S000003549; FungiDB:YJL012C; VEuPathDB:YJL012C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
PHM3; YJL012C-A
Summary
Enables calmodulin binding activity; inositol hexakisphosphate binding activity; and polyphosphate kinase activity. Involved in microautophagy; polyphosphate biosynthetic process; and vacuolar transport. Located in endoplasmic reticulum and vacuolar membrane. Part of vacuolar transporter chaperone complex. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See VTC4 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (411234..413399, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene chaperonin-containing T-complex subunit CCT3 Neighboring gene Mad3p Neighboring gene DNA-directed RNA polymerase III subunit RPC17 Neighboring gene tRNA-Lys

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Polyphosphate is involved in cell cycle progression and genomic stability in Saccharomyces cerevisiae. Bru S, et al. Mol Microbiol, 2016 Aug. PMID 27072996
  2. VTC4 Polyphosphate Polymerase Knockout Increases Stress Resistance of Saccharomyces cerevisiae Cells. Tomashevsky A, et al. Biology (Basel), 2021 May 30. PMID 34070801, Free PMC Article
  3. Transposon insertional mutagenesis in Saccharomyces uvarum reveals trans-acting effects influencing species-dependent essential genes. Sanchez MR, et al. Genome Res, 2019 Mar. PMID 30635343, Free PMC Article
  4. Inositol pyrophosphates activate the vacuolar transport chaperone complex in yeast by disrupting a homotypic SPX domain interaction. Pipercevic J, et al. Nat Commun, 2023 May 8. PMID 37156835, Free PMC Article
  5. Proteins required for vacuolar function are targets of lysine polyphosphorylation in yeast. McCarthy L, et al. FEBS Lett, 2020 Jan. PMID 31466120

See all (94) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results define Vtc4p* as a polyP-synthesizing enzyme
    Title: Catalytic core of a membrane-associated eukaryotic polyphosphate polymerase.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables calmodulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables inositol hexakisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables polyphosphate kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in microautophagy IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in microautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in polyphosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in polyphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in polyphosphate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in polyphosphate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vacuolar transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vacuolar transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in autophagosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
located_in cell periphery HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in fungal-type vacuole membrane HDA PubMed 
is_active_in fungal-type vacuole membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuolar membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
part_of vacuolar transporter chaperone complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of vacuolar transporter chaperone complex IEA
Inferred from Electronic Annotation
more info
  
part_of vacuolar transporter chaperone complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Vtc4p
NP_012522.2
  • Vacuolar membrane polyphosphate polymerase; subunit of vacuolar transporter chaperone (VTC) complex involved in synthesis and transfer of polyP to vacuole; regulates membrane trafficking; role in non-autophagic vacuolar fusion; targeted to vacuole via AP-3 pathway; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    411234..413399 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181446.1 → NP_012522.2  TPA: Vtc4p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012522.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWG5, P47075, Q7Z872, Q86ZR4
    UniProtKB/TrEMBL
    A6ZPV7, B3LQ90, B5VLG0, C7GSP3, C8ZBJ9, G2WGZ9, N1P0Y9
    Conserved Domains (2) summary
    COG5036
    Location:1 → 497
    COG5036; SPX domain-containing protein involved in vacuolar polyphosphate accumulation [Inorganic ion transport and metabolism, Intracellular trafficking, secretion, and vesicular transport]
    cl09954
    Location:593 → 721
    DUF202; Domain of unknown function (DUF202)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47075.2

Gene LinkOut

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