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APL1 Apl1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853461, updated on 4-Jan-2025

Summary

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Official Symbol
APL1
Official Full Name
Apl1p
Primary source
SGD:S000003765
Locus tag
YJR005W
See related
AllianceGenome:SGD:S000003765; FungiDB:YJR005W; VEuPathDB:YJR005W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YAP80
Summary
Predicted to enable clathrin binding activity. Predicted to be involved in vesicle-mediated transport. Located in endocytic vesicle. Part of AP-2 adaptor complex. Orthologous to human AP1B1 (adaptor related protein complex 1 subunit beta 1) and AP2B1 (adaptor related protein complex 2 subunit beta 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See APL1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (445923..448025)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Mrx12p Neighboring gene Sag1p Neighboring gene Lso1p Neighboring gene DNA-directed DNA polymerase delta subunit POL31

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of a putative yeast homolog of the mammalian beta chains of the clathrin-associated protein complexes. Kirchhausen T. Mol Cell Biol, 1990 Nov. PMID 2122239, Free PMC Article
  2. Saccharomyces cerevisiae Apl2p, a homologue of the mammalian clathrin AP beta subunit, plays a role in clathrin-dependent Golgi functions. Rad MR, et al. J Cell Sci, 1995 Apr. PMID 7615679
  3. Clathrin Adaptor Complex-interacting Protein Irc6 Functions through the Conserved C-Terminal Domain. Zhou H, et al. Sci Rep, 2019 Mar 14. PMID 30872642, Free PMC Article
  4. Clathrin interactions with C-terminal regions of the yeast AP-1 beta and gamma subunits are important for AP-1 association with clathrin coats. Yeung BG, et al. Traffic, 2001 Aug. PMID 11489214
  5. A systematic approach to identify recycling endocytic cargo depending on the GARP complex. Eising S, et al. Elife, 2019 Jan 29. PMID 30694181, Free PMC Article

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables clathrin binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IC
Inferred by Curator
more info
 PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of AP-2 adaptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud neck HDA PubMed 
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
  
located_in endocytic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
part_of membrane coat IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Apl1p
NP_012538.3
  • Beta-adaptin; large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    445923..448025
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181662.3 → NP_012538.3  TPA: Apl1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012538.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWH9, P27351
    UniProtKB/TrEMBL
    B3LQA3, N1P000
    Conserved Domains (1) summary
    COG5096
    Location:1 → 700
    COG5096; Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P27351.2

Gene LinkOut

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