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HOC1 alpha-1,6-mannosyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 853538, updated on 4-Jan-2025

Summary

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Official Symbol
HOC1
Official Full Name
alpha-1,6-mannosyltransferase
Primary source
SGD:S000003836
Locus tag
YJR075W
See related
AllianceGenome:SGD:S000003836; FungiDB:YJR075W; VEuPathDB:YJR075W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to alpha-1,6-mannosyltransferase activity. Predicted to be involved in protein N-linked glycosylation. Part of mannan polymerase complex. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See HOC1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (573981..575171)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Neighboring gene Ran GTPase-binding protein MOG1 Neighboring gene septin CDC11 Neighboring gene Mir1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Saccharomyces cerevisiae HOC1, a suppressor of pkc1, encodes a putative glycosyltransferase. Neiman AM, et al. Genetics, 1997 Mar. PMID 9055074, Free PMC Article
  2. Novel membrane protein complexes for protein glycosylation in the yeast Golgi apparatus. Hashimoto H, et al. Biochem Biophys Res Commun, 1997 Dec 29. PMID 9434768
  3. Multi-protein complexes in the cis Golgi of Saccharomyces cerevisiae with alpha-1,6-mannosyltransferase activity. Jungmann J, et al. EMBO J, 1998 Jan 15. PMID 9430634, Free PMC Article
  4. Interaction among the subunits of Golgi membrane mannosyltransferase complexes of the yeast Saccharomyces cerevisiae. Kojima H, et al. Biosci Biotechnol Biochem, 1999 Nov. PMID 10635561
  5. The Saccharomyces cerevisiae protein Mnn10p/Bed1p is a subunit of a Golgi mannosyltransferase complex. Jungmann J, et al. J Biol Chem, 1999 Mar 5. PMID 10037752

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to alpha-1,6-mannosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alpha-1,6-mannosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate derivative metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cell wall mannoprotein biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in substituted mannan metabolic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
part_of mannan polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mannan polymerase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mannan polymerase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alpha-1,6-mannosyltransferase
NP_012609.3
  • Alpha-1,6-mannosyltransferase; involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    573981..575171
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181733.3 → NP_012609.3  TPA: alpha-1,6-mannosyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012609.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWP5, E9P8X6, P47124
    UniProtKB/TrEMBL
    A6ZQ33, B3LQG1, C7GMC9, C8ZBM2, G2WH79, N1P154
    Conserved Domains (1) summary
    COG3774
    Location:7 → 396
    OCH1; Mannosyltransferase OCH1 or related enzyme [Cell wall/membrane/envelope biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47124.3

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