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uncharacterized protein [ Saccharomyces cerevisiae S288C ]

Gene ID: 853546, updated on 9-Dec-2024

Summary

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Official Full Name
uncharacterized protein
Primary source
SGD:S000003844
Locus tag
YJR084W
See related
AllianceGenome:SGD:S000003844; FungiDB:YJR084W; VEuPathDB:YJR084W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CSN12
Summary
Predicted to enable RNA binding activity and double-stranded DNA binding activity. Involved in cellular response to pheromone; conjugation with cellular fusion; and mRNA splicing, via spliceosome. Located in euchromatin. Orthologous to human PCID2 (PCI domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (583733..585004)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Eaf6p Neighboring gene Acf4p Neighboring gene Tmh11p Neighboring gene Ste18p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural assembly of the nucleic-acid-binding Thp3-Csn12-Sem1 complex functioning in mRNA splicing. Kuang Z, et al. Nucleic Acids Res, 2022 Aug 26. PMID 35904806, Free PMC Article
  2. The PAM domain, a multi-protein complex-associated module with an all-alpha-helix fold. Ciccarelli FD, et al. BMC Bioinformatics, 2003 Dec 19. PMID 14687415, Free PMC Article
  3. Conservation of the COP9/signalosome in budding yeast. Wee S, et al. BMC Genet, 2002 Aug 20. PMID 12186635, Free PMC Article
  4. COP9 signalosome components play a role in the mating pheromone response of S. cerevisiae. Maytal-Kivity V, et al. EMBO Rep, 2002 Dec. PMID 12446563, Free PMC Article
  5. The COP9 signalosome-like complex in S. cerevisiae and links to other PCI complexes. Maytal-Kivity V, et al. Int J Biochem Cell Biol, 2003 May. PMID 12672462

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. role in transcription elongation for Ypr045c (Thp3) and the Csn12 component of the COP9 signalosome
    Title: New suppressors of THO mutations identify Thp3 (Ypr045c)-Csn12 as a protein complex involved in transcription elongation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cellular response to pheromone IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in conjugation with cellular fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of COP9 signalosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in euchromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein
NP_012617.1
  • Protein that forms a complex with Thp3p; may have a role in transcription elongation and/or mRNA splicing; identified as a COP9 signalosome component but phenotype and interactions suggest it may not be involved with the signalosome

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    583733..585004
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181741.1 → NP_012617.1  TPA: uncharacterized protein YJR084W [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012617.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWQ3, P47130
    UniProtKB/TrEMBL
    A6ZQ40, B3LQG9, B5VLN4, C7GMC2, C8ZBN0, G2WH87, N1P1N1
    Conserved Domains (1) summary
    COG5600
    Location:1 → 423
    COG5600; Transcription-associated recombination protein [DNA replication, recombination, and repair]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47130.1

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