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FIP1 cleavage polyadenylation factor subunit FIP1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853555, updated on 4-Jan-2025

Summary

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Official Symbol
FIP1
Official Full Name
cleavage polyadenylation factor subunit FIP1
Primary source
SGD:S000003853
Locus tag
YJR093C
See related
AllianceGenome:SGD:S000003853; FungiDB:YJR093C; VEuPathDB:YJR093C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein-macromolecule adaptor activity. Contributes to RNA binding activity. Involved in mRNA processing. Part of mRNA cleavage and polyadenylation specificity factor complex. Orthologous to human FIP1L1 (factor interacting with PAPOLA and CPSF1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See FIP1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (603220..604203, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Jsn1p Neighboring gene Bud4p Neighboring gene transcription factor IME1 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The FIP1 gene encodes a component of a yeast pre-mRNA polyadenylation factor that directly interacts with poly(A) polymerase. Preker PJ, et al. Cell, 1995 May 5. PMID 7736590
  2. Structure of yeast poly(A) polymerase in complex with a peptide from Fip1, an intrinsically disordered protein. Meinke G, et al. Biochemistry, 2008 Jul 1. PMID 18537269, Free PMC Article
  3. Functional dissection of the zinc finger and flanking domains of the Yth1 cleavage/polyadenylation factor. Tacahashi Y, et al. Nucleic Acids Res, 2003 Mar 15. PMID 12626716, Free PMC Article
  4. Fip1 regulates the activity of Poly(A) polymerase through multiple interactions. Helmling S, et al. Mol Cell Biol, 2001 Mar. PMID 11238938, Free PMC Article
  5. Processivity of the Saccharomyces cerevisiae poly(A) polymerase requires interactions at the carboxyl-terminal RNA binding domain. Zhelkovsky A, et al. Mol Cell Biol, 1998 Oct. PMID 9742111, Free PMC Article

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. these results indicate that the Fip1 linker, through its flexibility and protein/protein interactions, allows Pap1 to reach the 3' end of the cleaved RNA and efficiently initiate poly(A) addition.
    Title: A flexible linker region in Fip1 is needed for efficient mRNA polyadenylation.
  2. in the absence of Pap1, Fip1 is largely, if not completely, unfolded
    Title: Structure of yeast poly(A) polymerase in complex with a peptide from Fip1, an intrinsically disordered protein.
  3. Data elucidate the role of Fip1 in the mRNA 3'-OH polyadenylation process.
    Title: Fip1--an essential component of the Saccharomyces cerevisiae polyadenylation machinery is phosophorylated by protein kinase CK2.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to RNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein-macromolecule adaptor activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables protein-macromolecule adaptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein-macromolecule adaptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of mRNA cleavage and polyadenylation specificity factor complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cleavage polyadenylation factor subunit FIP1
NP_012626.1
  • Subunit of cleavage polyadenylation factor (CPF); interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    603220..604203 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181750.1 → NP_012626.1  TPA: cleavage polyadenylation factor subunit FIP1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012626.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWR1, P45976
    UniProtKB/TrEMBL
    A6ZQ48, B5VLP1, C7GMB4, G2WH95, N1P8T4
    Conserved Domains (1) summary
    COG5213
    Location:8 → 301
    FIP1; Polyadenylation factor I complex, subunit FIP1 [RNA processing and modification]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P45976.1

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