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AIM25 Aim25p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853563, updated on 9-Dec-2024

Summary

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Official Symbol
AIM25
Official Full Name
Aim25p
Primary source
SGD:S000003861
Locus tag
YJR100C
See related
AllianceGenome:SGD:S000003861; FungiDB:YJR100C; VEuPathDB:YJR100C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SLM35
Summary
Predicted to enable phospholipid scramblase activity. Involved in cellular response to heat; cellular response to oxidative stress; and negative regulation of autophagy of mitochondrion. Located in mitochondrion. Orthologous to several human genes including PLSCR1 (phospholipid scramblase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See AIM25 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (616351..617334, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ubiquitin-specific protease YUH1 Neighboring gene tRNA-Leu Neighboring gene mitochondrial 37S ribosomal protein RSM26

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. TRA1, a novel mRNA highly expressed in leukemogenic mouse monocytic sublines but not in nonleukemogenic sublines. Kasukabe T, et al. Blood, 1997 Apr 15. PMID 9108418
  2. Slm35 links mitochondrial stress response and longevity through TOR signaling pathway. Aguilar-Lopez JL, et al. Aging (Albany NY), 2016 Dec 2. PMID 27922823, Free PMC Article
  3. INA complex liaises the F(1)F(o)-ATP synthase membrane motor modules. Naumenko N, et al. Nat Commun, 2017 Nov 1. PMID 29093463, Free PMC Article
  4. A yeast phenomic model for the gene interaction network modulating CFTR-ΔF508 protein biogenesis. Louie RJ, et al. Genome Med, 2012 Dec 27. PMID 23270647, Free PMC Article
  5. Assigning function to yeast proteins by integration of technologies. Hazbun TR, et al. Mol Cell, 2003 Dec. PMID 14690591

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables phospholipid scramblase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipid scramblase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to heat IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellular response to oxidative stress IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of autophagy of mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in plasma membrane phospholipid scrambling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in plasma membrane phospholipid scrambling IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Aim25p
NP_012634.3
  • Mitochondria hypothetical protein; interacts genetically with TOR1 to regulate chronological lifespan, and the response to both heat shock and oxidative stress; involved in maintaining the integrity of the mitochondrial network; negative regulator of mitophagy flux; non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant is viable and displays an elevated frequency of mitochondrial genome loss; similar to murine NOR1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    616351..617334 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181758.3 → NP_012634.3  TPA: Aim25p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012634.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWR9, P47140
    UniProtKB/TrEMBL
    A6ZQ56, B3LQI5, B5VLP7, C7GMA7, C8ZBP7, G2WHA3, N1P175
    Conserved Domains (1) summary
    pfam03803
    Location:59 → 310
    Scramblase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47140.1

Gene LinkOut

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