U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

VPS70 putative zinc metalloprotease [ Saccharomyces cerevisiae S288C ]

Gene ID: 853590, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
VPS70
Official Full Name
putative zinc metalloprotease
Primary source
SGD:S000003887
Locus tag
YJR126C
See related
AllianceGenome:SGD:S000003887; FungiDB:YJR126C; VEuPathDB:YJR126C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable carboxypeptidase activity. Involved in protein targeting to vacuole. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in several diseases, including abdominal aortic aneurysm; cerebral infarction; hemochromatosis (multiple); immunodeficiency 46; and multiple myeloma. Orthologous to several human genes including NAALAD2 (N-acetylated alpha-linked acidic dipeptidase 2); NAALADL1 (N-acetylated alpha-linked acidic dipeptidase like 1); and FOLH1 (folate hydrolase 1). [provided by Alliance of Genome Resources, Jan 2025]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See VPS70 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (656254..658689, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ent3p Neighboring gene Rsf2p Neighboring gene uncharacterized protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Improved linkage analysis of Quantitative Trait Loci using bulk segregants unveils a novel determinant of high ethanol tolerance in yeast. Duitama J, et al. BMC Genomics, 2014 Mar 19. PMID 24640961, Free PMC Article
  2. Adaptation to High Ethanol Reveals Complex Evolutionary Pathways. Voordeckers K, et al. PLoS Genet, 2015 Nov. PMID 26545090, Free PMC Article
  3. Gene-Environment Interactions in Stress Response Contribute Additively to a Genotype-Environment Interaction. Matsui T, et al. PLoS Genet, 2016 Jul. PMID 27437938, Free PMC Article
  4. Functional analysis of 150 deletion mutants in Saccharomyces cerevisiae by a systematic approach. Entian KD, et al. Mol Gen Genet, 1999 Dec. PMID 10628851
  5. Prevacuolar compartment morphology in vps mutants of Saccharomyces cerevisiae. Hedman JM, et al. Cell Biol Int, 2007 Oct. PMID 17543551

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables carboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein targeting to vacuole HMP PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
putative zinc metalloprotease
NP_012660.1
  • hypothetical protein involved in vacuolar protein sorting; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    656254..658689 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181784.1 → NP_012660.1  TPA: putative zinc metalloprotease [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012660.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWU5, P47161
    UniProtKB/TrEMBL
    G2WHC9, N1P3P3
    Conserved Domains (4) summary
    cd02121
    Location:187 → 413
    PA_GCPII_like; Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to the peptidase ...
    cd03874
    Location:419 → 649
    M28_PMSA_TfR_like; M28 Zn-peptidase Transferrin Receptor-like family
    pfam04253
    Location:731 → 799
    TFR_dimer; Transferrin receptor-like dimerization domain
    cl14876
    Location:135 → 187
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47161.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous