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KTI12 Kti12p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853750, updated on 9-Dec-2024

Summary

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Official Symbol
KTI12
Official Full Name
Kti12p
Primary source
SGD:S000001593
Locus tag
YKL110C
See related
AllianceGenome:SGD:S000001593; FungiDB:YKL110C; VEuPathDB:YKL110C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
TOT4
Summary
Enables chromatin binding activity. Involved in regulation of transcription by RNA polymerase II and tRNA wobble uridine modification. Located in cytoplasm and nucleus. Orthologous to human KTI12 (KTI12 chromatin associated homolog). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See KTI12 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (228939..229880, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene multifunctional nuclease RAD27 Neighboring gene DNA-binding protein ABF1 Neighboring gene transcription factor HAP4 Neighboring gene Sld2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Fungal Kti12 proteins display unusual linker regions and unique ATPase p-loops. Krutyhołowa R, et al. Curr Genet, 2020 Aug. PMID 32236652, Free PMC Article
  2. Kti12, a PSTK-like tRNA dependent ATPase essential for tRNA modification by Elongator. Krutyhołowa R, et al. Nucleic Acids Res, 2019 May 21. PMID 30916349, Free PMC Article
  3. Comparative analysis of the conserved functions of Arabidopsis DRL1 and yeast KTI12. Jun SE, et al. Mol Cells, 2015 Mar. PMID 25518926, Free PMC Article
  4. Dosage suppression of the Kluyveromyces lactis zymocin by Saccharomyces cerevisiae ISR1 and UGP1. Mehlgarten C, et al. FEMS Yeast Res, 2007 Aug. PMID 17367514
  5. Use of a Yeast tRNase Killer Toxin to Diagnose Kti12 Motifs Required for tRNA Modification by Elongator. Mehlgarten C, et al. Toxins (Basel), 2017 Sep 5. PMID 28872616, Free PMC Article

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. we demonstrate that Kti12 binds directly to Elongator and that ATP hydrolysis is crucial for Elongator to maintain proper tRNA anticodon modification levels in vivo
    Title: Kti12, a PSTK-like tRNA dependent ATPase essential for tRNA modification by Elongator.
  2. The conserved functions of Arabidopsis DRL1 and yeast KTI12 deomnstrated by genetic complementation.
    Title: Comparative analysis of the conserved functions of Arabidopsis DRL1 and yeast KTI12.
  3. close physical and functional relationship between Elongator and the highly conserved Kti12 protein
    Title: Physical and functional interaction between Elongator and the chromatin-associated Kti12 protein.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in tRNA wobble uridine modification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA wobble uridine modification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Kti12p
NP_012812.1
  • Protein that plays a role in modification of tRNA wobble nucleosides; protein plays role in tRNA wobble nucleoside modification with Elongator complex; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    228939..229880 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179676.1 → NP_012812.1  TPA: Kti12p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012812.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXH7, P34253, Q05155
    UniProtKB/TrEMBL
    A6ZZK6, C7GVK0, C8ZC65, G2WHS3, N1NZR8
    Conserved Domains (1) summary
    pfam08433
    Location:3 → 309
    KTI12; Chromatin associated protein KTI12
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34253.2

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