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putative short-chain dehydrogenase/reductase [ Saccharomyces cerevisiae S288C ]

Gene ID: 853753, updated on 4-Jan-2025

Summary

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Official Full Name
putative short-chain dehydrogenase/reductase
Primary source
SGD:S000001590
Locus tag
YKL107W
See related
AllianceGenome:SGD:S000001590; FungiDB:YKL107W; VEuPathDB:YKL107W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables aldehyde dehydrogenase (NAD+) activity. Involved in response to furfural. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (236141..237070)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene transcription factor HAP4 Neighboring gene Sld2p Neighboring gene uncharacterized protein Neighboring gene aspartate transaminase AAT1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. YKL107W from Saccharomyces cerevisiae encodes a novel aldehyde reductase for detoxification of acetaldehyde, glycolaldehyde, and furfural. Wang H, et al. Appl Microbiol Biotechnol, 2019 Jul. PMID 31115629
  2. The DNA sequence analysis of the HAP4-LAP4 region on chromosome XI of Saccharomyces cerevisiae suggests the presence of a second aspartate aminotransferase gene in yeast. Chéret G, et al. Yeast, 1993 Nov. PMID 8109175
  3. Genetic and proteomic evidences support the localization of yeast enolase in the cell surface. López-Villar E, et al. Proteomics, 2006 Apr. PMID 16544286
  4. Unstable tandem repeats in promoters confer transcriptional evolvability. Vinces MD, et al. Science, 2009 May 29. PMID 19478187, Free PMC Article
  5. The ubiquitin-proteasome system regulates meiotic chromosome organization. Yang X, et al. Proc Natl Acad Sci U S A, 2022 Apr 26. PMID 35439061, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables aldehyde dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in response to furfural IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative short-chain dehydrogenase/reductase
NP_012815.1
  • NADH-dependent aldehyde reductase; involved in the detoxification of acetaldehyde, glycolaldehyde, furfural, formaldehyde and propionaldehyde; localizes to the endoplasmic reticulum; member of the classical short-chain dehydrogenase/reductase (SDR) family

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    236141..237070
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179673.1 → NP_012815.1  TPA: putative short-chain dehydrogenase/reductase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012815.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXI0, P34251
    UniProtKB/TrEMBL
    A6ZZK9, C7GVK3, C8ZC68, G2WHS6, N1NZ31
    Conserved Domains (1) summary
    cl21454
    Location:26 → 285
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34251.1

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