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HOT13 Hot13p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853778, updated on 9-Dec-2024

Summary

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Official Symbol
HOT13
Official Full Name
Hot13p
Primary source
SGD:S000001567
Locus tag
YKL084W
See related
AllianceGenome:SGD:S000001567; FungiDB:YKL084W; VEuPathDB:YKL084W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables zinc ion binding activity. Involved in protein import into mitochondrial intermembrane space. Located in mitochondrial intermembrane space. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See HOT13 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (280509..280859)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene sulfiredoxin Neighboring gene malate dehydrogenase MDH1 Neighboring gene ribosome biosynthesis protein RRP14 Neighboring gene translation elongation factor EF1B gamma Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The zinc-binding protein Hot13 promotes oxidation of the mitochondrial import receptor Mia40. Mesecke N, et al. EMBO Rep, 2008 Nov. PMID 18787558, Free PMC Article
  2. The role of Hot13p and redox chemistry in the mitochondrial TIM22 import pathway. Curran SP, et al. J Biol Chem, 2004 Oct 15. PMID 15294910
  3. The S. cerevisiae m6A-reader Pho92 promotes timely meiotic recombination by controlling key methylated transcripts. Scutenaire J, et al. Nucleic Acids Res, 2023 Jan 25. PMID 35934316, Free PMC Article
  4. Complete DNA sequence of yeast chromosome XI. Dujon B, et al. Nature, 1994 Jun 2. PMID 8196765
  5. The cellular economy of the Saccharomyces cerevisiae zinc proteome. Wang Y, et al. Metallomics, 2018 Dec 12. PMID 30358795, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein import into mitochondrial intermembrane space IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into mitochondrial intermembrane space IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial intermembrane space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Hot13p
NP_012839.1
  • Zinc-binding mitochondrial intermembrane space (IMS) protein; involved in a disulfide relay system for IMS import of cysteine-containing proteins; binds Mia40p and stimulates its Erv1p-dependent oxidation, probably by sequestering zinc

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    280509..280859
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179650.1 → NP_012839.1  TPA: Hot13p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012839.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXK4, P36078, Q6Q598
    UniProtKB/TrEMBL
    B3LR08, C8ZC89, G2WHU9, N1P7S4
    Conserved Domains (1) summary
    COG4357
    Location:3 → 111
    COG4357; Uncharacterized protein, contains Zn-finger domain of CHY type [Function unknown]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36078.1

Gene LinkOut

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