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LPX2 Lpx2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853816, updated on 4-Jan-2025

Summary

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Official Symbol
LPX2
Official Full Name
Lpx2p
Primary source
SGD:S000001533
Locus tag
YKL050C
See related
AllianceGenome:SGD:S000001533; FungiDB:YKL050C; VEuPathDB:YKL050C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to be involved in eisosome assembly. Located in peroxisome. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See LPX2 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (342852..345620, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Ask1p Neighboring gene Sfk1p Neighboring gene centromeric DNA-binding histone H3-like protein CSE4 Neighboring gene serine/threonine protein kinase ELM1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Exploiting spore-autonomous fluorescent protein expression to quantify meiotic chromosome behaviors in Saccharomyces cerevisiae. Thacker D, et al. Genetics, 2011 Oct. PMID 21840861, Free PMC Article
  2. The function and properties of the Azf1 transcriptional regulator change with growth conditions in Saccharomyces cerevisiae. Slattery MG, et al. Eukaryot Cell, 2006 Feb. PMID 16467472, Free PMC Article
  3. Genome-wide surveys for phosphorylation-dependent substrates of SCF ubiquitin ligases. Tang X, et al. Methods Enzymol, 2005. PMID 16338374
  4. Mass-murdering: deletion of twenty-three ORFs from Saccharomyces cerevisiae chromosome XI reveals five genes essential for growth and three genes conferring detectable mutant phenotype. Wysocki R, et al. Gene, 1999 Mar 18. PMID 10095102
  5. Systematic multi-level analysis of an organelle proteome reveals new peroxisomal functions. Yifrach E, et al. Mol Syst Biol, 2022 Sep. PMID 36164978, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in eisosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Lpx2p
NP_012874.1
  • Peroxisomal matrix-localized lipase; target of SCFCdc4 ubiquitin ligase complex; peroxisomal, nuclear and cytosolic localization is dependent on the presence of oleate; transcription is regulated by Azf1p; LPX2 has a paralog, EIS1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    342852..345620 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179616.1 → NP_012874.1  TPA: Lpx2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012874.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXN7, P35736
    UniProtKB/TrEMBL
    B3LR39, N1P0M6
    Conserved Domains (1) summary
    pfam12757
    Location:347 → 466
    Eisosome1; Eisosome protein 1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35736.1

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