VPS24 ESCRT-III subunit protein VPS24 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: VPS24
Official Full Name: ESCRT-III subunit protein VPS24
Primary source: SGD:S000001524
Locus tag: YKL041W
See related: AllianceGenome:SGD:S000001524; FungiDB:YKL041W; VEuPathDB:YKL041W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: DID3; VPL26
Summary: Involved in ATP export; intralumenal vesicle formation; and late endosome to vacuole transport. Located in cytoplasm. Part of ESCRT III complex. Orthologous to human RNF103-CHMP3 (RNF103-CHMP3 readthrough) and CHMP3 (charged multivesicular body protein 3). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See VPS24 in Genome Data Viewer

Location:: chromosome: XI

Exon count:: 1

Sequence:: Chromosome: XI; NC_001143.9 (360143..360817)

Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Design principles of the ESCRT-III Vps24-Vps2 module.
Title: Design principles of the ESCRT-III Vps24-Vps2 module.
ESCRT-II coordinates the assembly of ESCRT-III filaments for cargo sorting and multivesicular body vesicle formation.
Title: ESCRT-II coordinates the assembly of ESCRT-III filaments for cargo sorting and multivesicular body vesicle formation.
Structure and disassembly of filaments formed by the ESCRT-III subunit Vps24.
Title: Structure and disassembly of filaments formed by the ESCRT-III subunit Vps24.
Impact of Vta1 and ESCRT-III family members on Vps4 ATPase activity.
Title: ESCRT-III family members stimulate Vps4 ATPase activity directly or via Vta1.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in ATP export	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endosome transport via multivesicular body sorting pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in intralumenal vesicle formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in late endosome to vacuole transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in late endosome to vacuole transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in vacuolar transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of ESCRT III complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ESCRT III complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in multivesicular body	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ESCRT-III subunit protein VPS24

NP_012883.1

One of four subunits of the ESCRT-III complex; forms an endosomal sorting complex required for transport III (ESCRT-III) subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001143.9 Reference assembly

Range

360143..360817

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179607.1 → NP_012883.1 TPA: ESCRT-III subunit protein VPS24 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012883.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VXP5, P36095

UniProtKB/TrEMBL

B3LR47, B5VMB5, C7GP32, C8ZCC9, N1P7W5

Conserved Domains (1) summary

COG5491
Location:26 → 224

Did4; Archaeal division protein CdvB, Snf7/Vps24/ESCRT-III family [Cell cycle control, cell division, chromosome partitioning]