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Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 85384, updated on 27-Nov-2024

Summary

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Official Symbol
Sos2provided by RGD
Official Full Name
SOS Ras/Rho guanine nucleotide exchange factor 2provided by RGD
Primary source
RGD:620435
See related
EnsemblRapid:ENSRNOG00000004826 AllianceGenome:RGD:620435
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Sos1
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Involved in positive regulation of small GTPase mediated signal transduction. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Noonan syndrome 9. Orthologous to human SOS2 (SOS Ras/Rho guanine nucleotide exchange factor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 116.0), Kidney (RPKM 88.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sos2 in Genome Data Viewer
Location:
6q24
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (93778971..93892161, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (88042966..88156140, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (91885292..92008059, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479215 Neighboring gene valosin containing protein lysine methyltransferase Neighboring gene acid phosphatase 1, pseudogene 1 Neighboring gene chloride intracellular channel protein 4 pseudogene Neighboring gene L-2-hydroxyglutarate dehydrogenase Neighboring gene distal membrane arm assembly component 2 like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Antipsychotic drug treatment induces differential gene expression in the rat cortex. Kontkanen O, et al. J Neurochem, 2002 Dec. PMID 12437575
  2. Src-dependent TrkA transactivation is required for pituitary adenylate cyclase-activating polypeptide 38-mediated Rit activation and neuronal differentiation. Shi GX, et al. Mol Biol Cell, 2010 May 1. PMID 20219970, Free PMC Article
  3. Functional redundancy of Sos1 and Sos2 for lymphopoiesis and organismal homeostasis and survival. Baltanás FC, et al. Mol Cell Biol, 2013 Nov. PMID 24043312, Free PMC Article
  4. Effect of long-term exercise on gene expression of insulin signaling pathway intermediates in skeletal muscle. Kim YB, et al. Biochem Biophys Res Commun, 1999 Jan 27. PMID 9920808
  5. Sam68 associates with the SH3 domains of Grb2 recruiting GAP to the Grb2-SOS complex in insulin receptor signaling. Najib S, et al. J Cell Biochem, 2002. PMID 12112020

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sam68 associates with the SH3 domains of Grb2 recruiting GAP to the Grb2-SOS complex in insulin receptor signaling
    Title: Sam68 associates with the SH3 domains of Grb2 recruiting GAP to the Grb2-SOS complex in insulin receptor signaling.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within B cell homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lymphocyte homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of small GTPase mediated signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of T cell differentiation in thymus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of pro-B cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within small GTPase-mediated signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
son of sevenless homolog 2
Names
son of sevenless 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135561.1 → NP_001129033.1  son of sevenless homolog 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A6HBX0, F1MAI3
    Related
    ENSRNOP00000098665.1, ENSRNOT00000140868.1
    Conserved Domains (7) summary
    smart00147
    Location:775 → 1019
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:596 → 740
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00160
    Location:200 → 387
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01261
    Location:438 → 544
    PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
    pfam00125
    Location:60 → 169
    Histone; Core histone H2A/H2B/H3/H4
    pfam00169
    Location:444 → 545
    PH; PH domain
    cl23907
    Location:97 → 147
    H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    93778971..93892161 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008764721.3 → XP_008762943.1  son of sevenless homolog 2 isoform X3

    UniProtKB/TrEMBL
    A0A0G2JVU2, A6HBX0
    Related
    ENSRNOP00000069620.2, ENSRNOT00000089891.3
    Conserved Domains (7) summary
    smart00147
    Location:742 → 986
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:563 → 707
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    smart00325
    Location:208 → 355
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01261
    Location:405 → 511
    PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
    pfam00125
    Location:60 → 169
    Histone; Core histone H2A/H2B/H3/H4
    pfam00169
    Location:411 → 512
    PH; PH domain
    cl23907
    Location:97 → 147
    H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...

  2. XM_039113012.2 → XP_038968940.1  son of sevenless homolog 2 isoform X1

    UniProtKB/TrEMBL
    A6HBX0
    Conserved Domains (5) summary
    smart00147
    Location:774 → 1018
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:595 → 739
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00160
    Location:200 → 386
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01261
    Location:437 → 543
    PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
    pfam00125
    Location:70 → 169
    Histone; Core histone H2A/H2B/H3/H4

  3. XM_039113013.2 → XP_038968941.1  son of sevenless homolog 2 isoform X2

    UniProtKB/TrEMBL
    A6HBX0
    Related
    ENSRNOP00000101962.1, ENSRNOT00000134978.1
    Conserved Domains (5) summary
    smart00147
    Location:775 → 1019
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:596 → 740
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00160
    Location:200 → 387
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01261
    Location:438 → 544
    PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
    pfam00125
    Location:70 → 169
    Histone; Core histone H2A/H2B/H3/H4

  4. XM_063262560.1 → XP_063118630.1  son of sevenless homolog 2 isoform X4

  5. XM_006240184.5 → XP_006240246.1  son of sevenless homolog 2 isoform X5

    UniProtKB/TrEMBL
    A6HBX0
    Conserved Domains (5) summary
    smart00147
    Location:603 → 847
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:424 → 568
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00160
    Location:28 → 215
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01261
    Location:266 → 372
    PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
    pfam00169
    Location:272 → 373
    PH; PH domain
Nucleotide Protein Strain
Heading Accession and Version

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