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RAM2 bifunctional protein farnesyltransferase/protein geranylgeranyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 853849, updated on 4-Jan-2025

Summary

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Official Symbol
RAM2
Official Full Name
bifunctional protein farnesyltransferase/protein geranylgeranyltransferase
Primary source
SGD:S000001502
Locus tag
YKL019W
See related
AllianceGenome:SGD:S000001502; FungiDB:YKL019W; VEuPathDB:YKL019W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables CAAX-protein geranylgeranyltransferase activity and protein farnesyltransferase activity. Involved in peptide pheromone maturation; protein farnesylation; and protein geranylgeranylation. Part of CAAX-protein geranylgeranyltransferase complex and protein farnesyltransferase complex. Orthologous to human FNTA (farnesyltransferase, CAAX box, subunit alpha). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See RAM2 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (402568..403518)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Mak11p Neighboring gene Spt23p Neighboring gene Mco12p Neighboring gene WD-repeat containing protein SWD2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sequence dependence of protein isoprenylation. Moores SL, et al. J Biol Chem, 1991 Aug 5. PMID 1860864
  2. Suppression of yeast geranylgeranyl transferase I defect by alternative prenylation of two target GTPases, Rho1p and Cdc42p. Ohya Y, et al. Mol Biol Cell, 1993 Oct. PMID 8298188, Free PMC Article
  3. CDC43 and RAM2 encode the polypeptide subunits of a yeast type I protein geranylgeranyltransferase. Mayer ML, et al. J Biol Chem, 1992 Oct 15. PMID 1400380
  4. Protein farnesyltransferase: production in Escherichia coli and immunoaffinity purification of the heterodimer from Saccharomyces cerevisiae. Mayer MP, et al. Gene, 1993 Sep 30. PMID 8406041
  5. Purified yeast protein farnesyltransferase is structurally and functionally similar to its mammalian counterpart. Gomez R, et al. Biochem J, 1993 Jan 1. PMID 8424764, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables CAAX-protein geranylgeranyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables CAAX-protein geranylgeranyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables prenyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein farnesyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein farnesyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein geranylgeranyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein geranylgeranyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein prenyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in peptide pheromone maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptide pheromone maturation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein farnesylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein geranylgeranylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of CAAX-protein geranylgeranyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CAAX-protein geranylgeranyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of protein farnesyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein farnesyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
bifunctional protein farnesyltransferase/protein geranylgeranyltransferase
NP_012906.3
  • Alpha subunit of farnesyltransferase and geranylgeranyltransferase-I; farnesyltransferase (Ram2p-Ram1p heterodimer) catalyzes the addition of 15-carbon isoprenoid farnesyl to substrate proteins containing a CAAX consensus motif; type I geranylgeranyltransferase (Ram2p-Cdc43p heterodimer) catalyzes the addition of the 20-carbon isoprenoid geranylgeranyl to substrate proteins containing a CaaL consensus motif; required for membrane localization of Ras proteins and a-factor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    402568..403518
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179585.3 → NP_012906.3  TPA: bifunctional protein farnesyltransferase/protein geranylgeranyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012906.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXR6, P29703
    UniProtKB/TrEMBL
    A6ZZU5, B3LR65, B5VMD6, C7GRH9, C8ZCE8, G2WI11, N1P0Q7
    Conserved Domains (1) summary
    COG5536
    Location:1 → 316
    BET4; Protein prenyltransferase, alpha subunit [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P29703.1

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