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ARC19 Arc19p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853856, updated on 4-Jan-2025

Summary

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Official Symbol
ARC19
Official Full Name
Arc19p
Primary source
SGD:S000001496
Locus tag
YKL013C
See related
AllianceGenome:SGD:S000001496; FungiDB:YKL013C; VEuPathDB:YKL013C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables molecular adaptor activity. Involved in actin cortical patch organization. Part of Arp2/3 protein complex. Used to study cancer. Orthologous to human ARPC4 (actin related protein 2/3 complex subunit 4). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See ARC19 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (417508..418023, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Put3p Neighboring gene Urb1p Neighboring gene Prp40p Neighboring gene cruciform cutting endonuclease

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Affinity filtration coupled with capillary-based affinity purification for the isolation of protein complexes. Qureshi MS, et al. Anal Biochem, 2013 Aug 1. PMID 23583819
  2. Genetic dissection of the budding yeast Arp2/3 complex: a comparison of the in vivo and structural roles of individual subunits. Winter DC, et al. Proc Natl Acad Sci U S A, 1999 Jun 22. PMID 10377407, Free PMC Article
  3. Mechanism of filament nucleation and branch stability revealed by the structure of the Arp2/3 complex at actin branch junctions. Egile C, et al. PLoS Biol, 2005 Nov. PMID 16262445, Free PMC Article
  4. Purification of Arp2/3 complex from Saccharomyces cerevisiae. Doolittle LK, et al. Methods Mol Biol, 2013. PMID 23868593, Free PMC Article
  5. Arp2/3 complex and actin dynamics are required for actin-based mitochondrial motility in yeast. Boldogh IR, et al. Proc Natl Acad Sci U S A, 2001 Mar 13. PMID 11248049, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular adaptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Arp2/3 complex-mediated actin nucleation IEA
Inferred from Electronic Annotation
more info
  
involved_in actin cortical patch organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in actin filament polymerization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Arp2/3 protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Arp2/3 protein complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Arp2/3 protein complex IEA
Inferred from Electronic Annotation
more info
  
located_in actin cortical patch IEA
Inferred from Electronic Annotation
more info
  
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Arc19p
NP_012912.1
  • Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; mutation is functionally complemented by human ARPC4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    417508..418023 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179579.1 → NP_012912.1  TPA: Arc19p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012912.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXS3, P33204
    UniProtKB/TrEMBL
    A6ZZV2, B3LR71, C7GRH2, C8ZCF4, G2WI18, N1NZB9
    Conserved Domains (1) summary
    pfam05856
    Location:1 → 166
    ARPC4; ARP2/3 complex 20 kDa subunit (ARPC4)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P33204.2

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