DID4 ESCRT-III subunit protein DID4 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: DID4
Official Full Name: ESCRT-III subunit protein DID4
Primary source: SGD:S000001485
Locus tag: YKL002W
See related: AllianceGenome:SGD:S000001485; FungiDB:YKL002W; VEuPathDB:YKL002W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CHM2; GRD7; REN1; VPL2; VPS14; VPS2; VPT14
Summary: Involved in several processes, including ATP export; intralumenal vesicle formation; and protein retention in Golgi apparatus. Located in cytoplasm. Part of ESCRT III complex. Used to study frontotemporal dementia and/or amyotrophic lateral sclerosis 7. Orthologous to human CHMP2A (charged multivesicular body protein 2A). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See DID4 in Genome Data Viewer

Location:: chromosome: XI

Exon count:: 2

Sequence:: Chromosome: XI; NC_001143.9 (437778..438544)

Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Design principles of the ESCRT-III Vps24-Vps2 module.
Title: Design principles of the ESCRT-III Vps24-Vps2 module.
Binding of Vps4 to ESCRT-III, coordinated by interactions with Vps2 and Snf7, is coupled to membrane neck constriction during intraluminal vesicle formation.
Title: Coordinated binding of Vps4 to ESCRT-III drives membrane neck constriction during MVB vesicle formation.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in ATP export	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endosome transport via multivesicular body sorting pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in intralumenal vesicle formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in late endosome to vacuole transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in late endosome to vacuole transport	IDA Inferred from Direct Assay more info	PubMed
involved_in protein retention in Golgi apparatus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in vacuolar transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of ESCRT III complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ESCRT III complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in multivesicular body	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ESCRT-III subunit protein DID4

NP_012924.2

Class E Vps protein of the ESCRT-III complex; required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001143.9 Reference assembly

Range

437778..438544

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179568.1 → NP_012924.2 TPA: ESCRT-III subunit protein DID4 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012924.2

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VXT5, P36108

UniProtKB/TrEMBL

A6ZZW4, B3LR83, C8ZCG5, N1P0F4

Conserved Domains (1) summary

COG5491
Location:38 → 229

Did4; Archaeal division protein CdvB, Snf7/Vps24/ESCRT-III family [Cell cycle control, cell division, chromosome partitioning]